EC Number   |
Subunits |
Reference |
|---|
   2.7.11.23 | dimer |
1 * 67000 + 1 * 83000, component B, SDS-PAGE |
640980 |
| 2.7.11.23 | More |
- |
490907 |
| 2.7.11.23 | More |
BRD4 domain mapping by mass spectrometry, comparison of kinase subdomain architecture and organization of eukaryotic protein kinases and atypical protein kinases, overview |
741328 |
| 2.7.11.23 | More |
cyclin K is associated with purified dCDK12, implicating it as the cyclin subunit of this CTD kinase |
740509 |
| 2.7.11.23 | More |
enzymes from mouse consist of 2 components each: cdc2/p58: a cdc2 kinase (p34) and a p58 subunit, cdc2/p62: a cdc2 kinase and a p62 subunit (cyclin B), the latter is also called M phase-specific histone H1 kinase |
490907, 640978 |
| 2.7.11.23 | More |
the enzyme Ctk3 consists of a N-terminal CTD-interacting domain (CID) and a C-terminal three helix bundle domain. The structure reveals eight helices arranged into a right-handed superhelical fold. Ctk3 shows no binding to CTD peptides. Structure and function of the CTDK-I complex, overview. Ctk1 (Lsk1) associates with its cyclin partner Ctk2 (Lsc1) and a third subunit, Ctk3 (Lsg1), to form the CTD kinase I (CTDK-I) complex. This trimeric structure is unique amongst CDK complexes. The Ctk3 N-terminal domain has a noncanonical surface |
741382 |
| 2.7.11.23 | More |
the three CTD kinase isozymes possess CDK-cyclin pairs, and TFIIH additionally forms a preinitiation complex, overview |
680554 |
| 2.7.11.23 | More |
three specific subunits: Ctk1 is the catalytic subunit, Ctk2 is a catalytic subunit, Ctk3 is unknown in its function but the physical interaction betwenn Ctk2 and Ctk3 is neccesary for kinase activity and protects both subunits against degradation |
640988 |
| 2.7.11.23 | trimer |
tentatively alphabetagamma, 1 * 58000 + 1 * 38000 + 1 * 32000, SDS-PAGE |
640975 |
