2.6.1.83 | homodimer |
VsDapL exists in a monomer-dimer self-association, with a KD2-1 of 0.0074 mM, a canonical dimer of chalice-shaped monomers, small-angle X-ray scattering experiments confirm the dimer in solution. Although the dimer interface buries 18% of the total surface area, several loops that contribute to the interface and active site, notably the L1, L2, and L5 loops, are highly mobile, perhaps explaining the unstable dimer and lower catalytic activity |
758829 |