EC Number   |
Subunits |
Reference |
|---|
   3.4.22.64 | dimer |
activation through dimerization |
731613 |
| 3.4.22.64 | dimer |
caspases are expressed in most cells as inactive monomeric zymogens (pro-caspases), requiring processing and heterodimerization to facilitate their activation |
772221 |
| 3.4.22.64 | dimer |
inducible dimerization activates caspase-11. Formation of a functional Casp11 inflammasome supramolecular organizing center (SMOC) involves additional steps beyond inducible dimerization, overview |
770759 |
| 3.4.22.64 | More |
caspase-11 catalytic activity and autoprocessing at the interdomain linker are required for spontaneous caspase-11 oligomerization in recombinant HEK293T cells |
770759 |
| 3.4.22.64 | More |
caspase-11 contains two components, an N-terminal caspase recruitment domain (CARD) and a C-terminal catalytic domain. The MBP-tagged caspase-11 CARD domain tetramerizes in solution. An extensive hydrophobic interface formed by the H1-2 helix mediates homotypic CARD interactions. The CARD mediates caspase oligomerization through CARD CARD interaction. The CARD of caspase-11 is essential for LPS-induced pyroptosis. Overall crystal structure of the caspase-11 CARD, overview |
770172 |
