EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
5.6.1.9 | 2 ATP + a reduced ferredoxin + inactive 2-hydroxyglutaryl-CoA dehydratase + 2 H2O |
a two [4Fe-4S]-cluster-containing ferredoxin with redox potentials of -405 mV and -340 mV can serve as an alternative electron donor |
Acidaminococcus fermentans |
2 ADP + 2 phosphate + an oxidized ferredoxin + active 2-hydroxyglutaryl-CoA dehydratase |
- |
? |
5.6.1.9 | 2 ATP + a reduced ferredoxin + inactive 2-hydroxyglutaryl-CoA dehydratase + 2 H2O |
a two [4Fe-4S]-cluster-containing ferredoxin with redox potentials of -405 mV and -340 mV can serve as an alternative electron donor |
Acidaminococcus fermentans DSM 20731 |
2 ADP + 2 phosphate + an oxidized ferredoxin + active 2-hydroxyglutaryl-CoA dehydratase |
- |
? |
5.6.1.9 | 2 ATP + a reduced flavodoxin + inactive 2-hydroxyglutaryl-CoA dehydratase + 2 H2O |
- |
Acidaminococcus fermentans |
2 ADP + 2 phosphate + a flavodoxin semiquinone + active 2-hydroxyglutaryl-CoA dehydratase |
- |
? |
5.6.1.9 | 2 ATP + a reduced flavodoxin + inactive 2-hydroxyglutaryl-CoA dehydratase + 2 H2O |
only catalytic amounts of activator HgdC are required for complete activation of the dehydratase |
Acidaminococcus fermentans |
2 ADP + 2 phosphate + a flavodoxin semiquinone + active 2-hydroxyglutaryl-CoA dehydratase |
- |
? |
5.6.1.9 | 2 ATP + a reduced flavodoxin + inactive 2-hydroxyglutaryl-CoA dehydratase + 2 H2O |
- |
Acidaminococcus fermentans DSM 20731 |
2 ADP + 2 phosphate + a flavodoxin semiquinone + active 2-hydroxyglutaryl-CoA dehydratase |
- |
? |
5.6.1.9 | 2 ATP + a reduced flavodoxin + inactive 2-hydroxyglutaryl-CoA dehydratase + 2 H2O |
only catalytic amounts of activator HgdC are required for complete activation of the dehydratase |
Acidaminococcus fermentans DSM 20731 |
2 ADP + 2 phosphate + a flavodoxin semiquinone + active 2-hydroxyglutaryl-CoA dehydratase |
- |
? |
5.6.1.9 | 2 ATP + a reduced flavodoxin + inactive 2-hydroxyisocaproyl-CoA dehydratase + 2 H2O |
- |
Clostridioides difficile |
2 ADP + 2 phosphate + a flavodoxin semiquinone + active 2-hydroxyisocaproyl-CoA dehydratase |
- |
? |
5.6.1.9 | 2 ATP + a reduced flavodoxin + inactive phenyllactate dehydratase + 2 H2O |
- |
Clostridium sporogenes |
2 ADP + 2 phosphate + a flavodoxin semiquinone + active phenyllactate dehydratase |
- |
? |
5.6.1.9 | more |
the activation of the dehydratase requires only ATP |
Acidaminococcus fermentans |
? |
- |
? |
5.6.1.9 | more |
oxidized component A exhibits ATPase activity of 6 s-1, which is completely abolished upon reduction by one electron. In the presence of ATP, one electron is transferred from flavodoxin hydroquinone via the [4Fe-4S]1+/2+ cluster of component A to Mo(VI) of 2-hydroxyglutaryl-CoA dehydratase, which is thereby reduced to Mo(V) |
Acidaminococcus fermentans |
? |
- |
? |