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Results 1 - 8 of 8
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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the reaction diagram Show all sequences 5.4.99.2323S rRNA uridine1911/uridine1915/uridine1917 - Escherichia coli 23S rRNA pseudouridine1911/pseudouridine1915/pseudouridine1917 - ?
Display the reaction diagram Show all sequences 5.4.99.2323S rRNA uridine1911/uridine1915/uridine1917 pseudouridine synthase RluD converts uridines at positions 1911, 1915, and 1917 of 23S rRNA to pseudouridines. These nucleotides are located in the functionally important helix-loop 69 of 23S rRNA. RluD is the only pseudouridine synthase that is required for normal growth in Escherichia coli Escherichia coli 23S rRNA pseudouridine1911/pseudouridine1915/pseudouridine1917 - ?
Display the reaction diagram Show all sequences 5.4.99.2323S rRNA uridine1911/uridine1915/uridine1917 RluD is far more efficient in modifying uridine residues in helix 69 in structured 50S subunits, compared to free or synthetic 23S rRNA. It is suggested that pseudouridine modifications in helix 69 are made late in the assembly of 23S rRNA into mature 50S subunits Escherichia coli 23S rRNA pseudouridine1911/pseudouridine1915/pseudouridine1917 - ?
Display the reaction diagram Show all sequences 5.4.99.2323S rRNA uridine1911/uridine1915/uridine1917 pseudouridine synthase RluD converts uridines at positions 1911, 1915, and 1917 of 23S rRNA to pseudouridines. These nucleotides are located in the functionally important helix-loop 69 of 23S rRNA. RluD isomerizes uridine in vivo only at positions 1911, 1915, and 1917, regardless of the presence of uridine at other positions in the loop of helix 69 of 23S rRNA variants. Substitution of one uridine by cytosine has no effect on the conversion of others (i.e. formation of pseudouridines at positions 1911, 1915, and 1917 are independent of each other). The substrate specificity of the pseudouridine synthase RluD is analyzed in vivo by using 23S rRNA variants. A1916 is the only position in the loop of helix 69, where mutations affect the RluD specific pseudouridine formation Escherichia coli 23S rRNA pseudouridine1911/pseudouridine1915/pseudouridine1917 - ?
Display the reaction diagram Show all sequences 5.4.99.2323S rRNA uridine1911/uridine1915/uridine1917 RluD is far more efficient in modifying uridine residues in helix 69 in structured 50S subunits, compared to free or synthetic 23S rRNA Escherichia coli 23S rRNA pseudouridine1911/pseudouridine1915/pseudouridine1917 - ?
Display the reaction diagram Show all sequences 5.4.99.2323S rRNA uridine1911/uridine1915/uridine1917 the enzyme is responsible in vivo for synthesis of the three pseudouridines clustered in a stem-loop at positions 1911, 1915, and 1917 of 23S RNA Escherichia coli 23S rRNA pseudouridine1911/pseudouridine1915/pseudouridine1917 - ?
Display the reaction diagram Show all sequences 5.4.99.2323S rRNA uridine1911/uridine1915/uridine1917 - Escherichia coli RluD 23S rRNA pseudouridine1911/pseudouridine1915/pseudouridine1917 - ?
Display the reaction diagram Show all sequences 5.4.99.23more the recombinant chimeric enzyme mutant RluCD isomerizes many uridines of rRNA in a non-specific manner Escherichia coli ? - ?
Results 1 - 8 of 8
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