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Results 1 - 3 of 3

EC Number	Substrates	Commentary Substrates	Organism	Products	Commentary (Products)	Reversibility
5.4.99.21	23S rRNA uridine2604	-	Escherichia coli	23S rRNA pseudouridine2604	-	?
5.4.99.21	23S rRNA uridine2604	it appears that YjbC is not completely specific for uridine2604 but can, to a small extent also react with uridine2605. The enzyme has an essential aspartate residue, at position 107	Escherichia coli	23S rRNA pseudouridine2604	-	?
5.4.99.21	23S rRNA uridine2604	RluF does not modify U2604 in rRNA mutant stem-loops that lack the A2602 bulge and shows dramatically higher activity for a stem-loop with a mutation designed to facilitate A2602 refolding into the stem with concomitant RNA strand translation. The substrate of RluF undergoes radical structural rearrangements upon binding. The RluF target base lies in an RNA stem rather than in a flexible loop and the substrate conformational change requires disruption of multiple base pairs. This energetically costly process is driven by interactions of the RNA with the protein	Escherichia coli	23S rRNA pseudouridine2604	-	?

Results 1 - 3 of 3

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Release 2023.1 (January 2023)