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Results 1 - 10 of 54 > >>
EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.131-phosphatidyl-1D-myo-inositol - Bacillus cereus 1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol - ?
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.131-phosphatidyl-1D-myo-inositol natural substrate Bacillus cereus 1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol - ?
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.131-phosphatidyl-1D-myo-inositol a catalytic diad at the active site composed of Asp-274 and His-32 is involved in substrate-assisted catalysis, its function is to hydrogen-bond with the 2-OH of phosphatidylinositol to form a catalytic triad, catalytic mechanism Bacillus cereus 1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol PI-PLC catalyzes in a second step the slow hydrolysis of 1D-myo-inositol 1,2-cyclic phosphate to form myo-inositol 1-phosphate ?
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.131-phosphatidyl-1D-myo-inositol aggregated substrate is preferred over monomeric substrate Bacillus thuringiensis 1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol a cyclic phosphodiesterase activity of PI-PLC converts 1D-myo-inositol 1,2-cyclic phosphate to inositol 1-phosphate ?
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.131-phosphatidyl-1D-myo-inositol catalytic mechanism, role of Arg-69, the bidentate nature of Arg-69 is the origin of the large thio effects and stereoselectivity in PI-PLC, its function is to bring the phosphate group and the 2-OH group of inositol into proximity and to induce proper alignment for nucleophilic attack, and possibly to lower the pKa of the 2-OH Bacillus sp. (in: Bacteria) 1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol - ?
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.131-phosphatidyl-1D-myo-inositol catalyzes the cleavage of the phosphorus-oxygen bond in phosphatidylinositol, catalytic role of aspartate in a short strong hydrogen bond of the Asp274-His32 catalytic dyad, catalytic mechanism, active site structure Bacillus thuringiensis 1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol - ?
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.131-phosphatidyl-1D-myo-inositol cleaves phosphatidylinositol in a rapid intramolecular transphosphorylation reaction forming the products, in a second reaction the cyclic phosphorylase activity of PI-PLC catalyzes the slow hydrolysis of 1D-myo-inositol 1,2-cyclic phosphate to D-myo-inositol 1-phosphate, utilizes His-32 and His-82 in a general acid catalysis mechanism Bacillus cereus 1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol - ?
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.131-phosphatidyl-1D-myo-inositol general acid/general base mechanism, enhanced activity when phosphatidylinositol is present in an interface compared to monomeric substrate Bacillus thuringiensis 1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol PI-PLC catalyzes the hydrolysis of myo-inositol 1,2-cyclic phosphate to myo-inositol 1-phosphate ?
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.131-phosphatidyl-1D-myo-inositol PLC accepts only nonphosphorylated phosphatidylinositol substrates and produces cyclic inositol phosphate as final product, which is hydrolyzed at a 1000fold lower rate, catalytic mechanism, uses a guanidinium group of Arg-69 during catalysis Bacillus sp. (in: Bacteria) 1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol - ?
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.131-phosphatidyl-1D-myo-inositol the active site is located at the C-terminal side Bacillus thuringiensis 1D-myo-inositol 1,2-cyclic phosphate + diacylglycerol - ?
Results 1 - 10 of 54 > >>