EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   4.2.3.39 | (2E,6E)-farnesyl diphosphate |
- |
Artemisia annua |
8-epi-cedrol + diphosphate |
- |
? |
| 4.2.3.39 | (2E,6E)-farnesyl diphosphate + H2O |
- |
Artemisia annua |
8-epi-cedrol + diphosphate |
- |
? |
| 4.2.3.39 | (2E,6E)-farnesyl diphosphate + H2O |
the enzyme is involved in the artemisinin biosynthesis pathway, overview |
Artemisia annua |
8-epi-cedrol + diphosphate |
- |
? |
| 4.2.3.39 | (2E,6E)-farnesyl diphosphate + H2O |
the native enzyme is specific for farnesyl diphosphate as substrate |
Artemisia annua |
8-epi-cedrol + diphosphate |
- |
? |
| 4.2.3.39 | (2E,6E)-farnesyl diphosphate + H2O |
the native enzyme is specifically producing 8-epi-cedrol, but the enzyme recombinantly expressed in Escherichia coli also produces cedrol, with 8-epi-cedrol and cedrol in a 96:4 ratio, GC-MS product analysis, overview |
Artemisia annua |
8-epi-cedrol + diphosphate |
- |
? |
| 4.2.3.39 | geranyl diphosphate + H2O |
geranyl diphosphate is converted to monoterpenes by the recombinant enzyme at a rate of about 15% of that observed with farnesyl diphosphate as substrate |
Artemisia annua |
? + diphosphate |
- |
? |
| 4.2.3.39 | more |
Sesquiterpene cyclases or synthases catalyze the conversion of the isoprenoid intermediate farnesyl diphosphate to various sesquiterpene structural types |
Artemisia annua |
? |
- |
? |
| 4.2.3.39 | more |
product formation specificity, overview. Native epi-cedrol synthase is not active with geranylgeranyl diphosphate as substrate. The recombinant enzyme catalyzes the formation of both olefinic sesquiterpene, i.e. 57% alpha-cedrene, 13% beta-cedrene, 5% (E)-beta-farnesene , 1% alpha-acoradiene, 8% (E)-alpha-bisabolene, and 16% of three unknown olefins, but mainly oxygenates sesquiterpenes, 97% of total sesquiterpene generated, composed of 96% epi-cedrol and 4% cedrol, from farnesyl diphosphate, GC-MS product analysis, overview |
Artemisia annua |
? |
- |
? |
