EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
4.2.3.32 | (+)-copalyl diphosphate |
- |
Picea abies |
abieta-8(14),12-diene + diphosphate |
- |
? |
4.2.3.32 | (+)-copalyl diphosphate |
- |
Ginkgo biloba |
abieta-8(14),12-diene + diphosphate |
- |
? |
4.2.3.32 | (+)-copalyl diphosphate |
- |
Ginkgo biloba |
abieta-8(14),12-diene + diphosphate |
products are levopimaradiene, abieta-7,13-diene, and sandaracopimaradiene |
? |
4.2.3.32 | (+)-copalyl-diphosphate |
reaction intermediate is C8-sandaracopimaradienyl cation |
Picea abies |
(-)-abietadiene + levopimaradiene + neoabietadiene + palustradiene + diphosphate |
bifunctional levopimaradiene/abietadiene synthase produces a mixture of diterpenes |
? |
4.2.3.32 | (+)-copalyl-diphosphate |
reaction intermediate is C8-sandaracopimaradienyl cation |
Pinus taeda |
(-)-abietadiene + levopimaradiene + neoabietadiene + palustradiene + diphosphate |
bifunctional levopimaradiene/abietadiene synthase, about 47% levopimaradiene, 27% abietadiene, 22% neoabietadiene, 3% palustradiene |
? |
4.2.3.32 | (+)-copalyl-diphosphate |
reaction intermediate is labdadienyl diphosphate |
Ginkgo biloba |
levopimaradiene + diphosphate |
- |
? |
4.2.3.32 | (+)-copalyl-diphosphate |
- |
Picea abies |
13-hydroxy-8(14)-abietene + diphosphate |
the initial products formed and released in vitro are unstable alcohols identified as epimeric thermally unstable allylic tertiary alcohols, 13-hydroxy-8(14)-abietene. The dehydration of the alcohol products, yielding the well established diterpene products levopimaradiene, abietadiene, neoabietadiene, and palustradiene, occurs due to the conditions of the GC-MS analysis typically used |
? |
4.2.3.32 | more |
catalyzes an intermediate step in synthesis of ginkgolide A |
Ginkgo biloba |
? |
- |
? |
4.2.3.32 | more |
abietadiene synthase (PaLAS) is a bifunctional terpene synthase that catalyzes both class I and class II reactions, i.e. formation of (+)-copalyl diphosphate from geranylgeranyl diphosphate (cf. EC 5.5.1.12, class II diTPS), and formation of abieta-8(14),12-diene from (+)-copalyl diphosphate (EC 4.2.3.32, class I diTPS) |
Picea abies |
? |
- |
? |