EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
4.2.3.141 | (13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate + H2O |
i.e. 8alpha-hydroxy-copalyl diphosphate |
Salvia sclarea |
(13R)-sclareol + diphosphate |
- |
? |
4.2.3.141 | (13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate + H2O |
i.e. 8alpha-hydroxy-copalyl diphosphate, the enzyme shows strong stereoselectivity in formation of the (13R)-epimer, residue N431 is responsible |
Salvia sclarea |
(13R)-sclareol + diphosphate |
- |
? |
4.2.3.141 | (13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate + H2O |
- |
Salvia sclarea |
sclareol + diphosphate |
- |
? |
4.2.3.141 | (9S,10S)-copalyl diphosphate + H2O |
- |
Salvia sclarea |
manool + diphosphate |
- |
? |
4.2.3.141 | labda-13-en-8-ol diphosphate + H2O |
- |
Salvia sclarea |
sclareol + diphosphate |
- |
? |
4.2.3.141 | more |
in coupled enzyme assays with labda-13-en-8-ol diphosphate synthase, sclareol is the major product with minor amounts of manool, manoyl oxides and epi-manoyl oxide as secondary products |
Salvia sclarea |
? |
- |
? |
4.2.3.141 | more |
no substrate: geranylgeranyl diphosphate |
Salvia sclarea |
? |
- |
? |
4.2.3.141 | more |
GC-MS reaction product analysis |
Salvia sclarea |
? |
- |
? |
4.2.3.141 | more |
GC-MS reaction product analysis. Molecular docking of enzyme products in to the active site of the enzyme, modeling, overview |
Salvia sclarea |
? |
- |
? |