EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
  4.2.3.133 | (2E,6E)-farnesyl diphosphate |
- |
Ricinus communis |
(+)-delta-cadinene + diphosphate |
yield of 40% (+)-delta-cadinene |
? |
| 4.2.3.133 | (2E,6E)-farnesyl diphosphate |
- |
Solanum tuberosum |
(-)-alpha-copaene + diphosphate |
- |
? |
| 4.2.3.133 | (2E,6E)-farnesyl diphosphate |
- |
Citrus sinensis |
(-)-alpha-copaene + diphosphate |
- |
? |
| 4.2.3.133 | (2E,6E)-farnesyl diphosphate |
- |
Ricinus communis |
(-)-alpha-copaene + diphosphate |
yield of 60% (-)-alpha-copaene |
? |
| 4.2.3.133 | (2E,6E)-farnesyl diphosphate |
- |
Ricinus communis |
(-)-alpha-copaene + diphosphate |
products are about 60% (-)-alpha-copaene, 40% (+)-delta-cadinene |
? |
| 4.2.3.133 | (2E,6E)-farnesyl diphosphate |
- |
Helianthus annuus |
alpha-copaene + diphosphate |
delta-cadinene is one of the two main products, while alpha-muuorlene, beta-caryophyllene, alpha-humulene and alpha-copaene are minor products |
? |
| 4.2.3.133 | 2 (2E,6E)-farnesyl diphosphate |
- |
Phyla dulcis |
alpha-copaene + delta-cadinene + 2 diphosphate |
bifunctional sesquiterpene synthase producing both alpha-copaene and delta-cadinene |
? |
| 4.2.3.133 | 2 (2E,6E)-farnesyl diphosphate |
- |
Liquidambar formosana |
(-)-alpha-copaene + delta-cadinene + 2 diphosphate |
- |
? |
| 4.2.3.133 | geranylgeranyl diphosphate + H2O |
it is proposed that a basic amino acid residue of the enzyme abstracts a proton from a molecule of water as the hydroxyl adds to the double bond at carbon7 of geranylgeranyl diphosphate. Concerted cyclization occurs and the double bond at carbon14 of geranylgeranyl diphosphate (carbon-3 of (8R)-hydroxy-copalyl diphosphate) is protonated. This concerted mechanism accounts for the addition of a single atom of 18O and a single atom of deuterium to geranylgeranyl diphosphate to form (8R)-hydroxy-copalyl diphosphate |
Salvia sclarea |
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate |
first step in synthesis of sclareol |
? |
