EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
4.2.3.126 | (2E,6E)-farnesyl diphosphate |
- |
Coprinopsis cinerea |
gamma-muurolene + diphosphate |
- |
? |
4.2.3.126 | (2E,6E)-farnesyl diphosphate |
- |
Santalum album |
gamma-muurolene + diphosphate |
SasesquiTPS1 with (2E,6E)-farnesyl diphosphate as substrate produces a complex mixture of mono- and bicyclic sesquiterpenes. The main products as analysed by GC-MS and GC-FID are the cyclic alcohol germacrene D-4-ol, and helminthogermacrene. Also present are alpha-bulnesene, gamma-muurolene, alpha- and beta-selinenes, as well as several other minor bicyclic compounds, alpha-humulene and nerolidol are detected in proportions below 5% |
? |
4.2.3.126 | (2E,6E)-farnesyl diphosphate |
significant amounts of beta-elemene, gamma-muurolene, germacrene D, and delta-cadinene are synthesized in the headspace of Cop3 cultures |
Coprinopsis cinerea |
gamma-muurolene + diphosphate |
- |
? |
4.2.3.126 | (2E,6E)-farnesyl diphosphate |
the major cyclization products of Cop3 and its loop mutants are derived from an E,E-germacradienyl cation formed after ionization and 1,10 cyclization of E,E-farnesyl diphosphate. alpha-Muurolene is 30% of the products formed from (2E,6E)-farnesyl diphosphate |
Coprinopsis cinerea |
gamma-muurolene + diphosphate |
gamma-muurolene is 12% of the products formed from (2E,6E)-farnesyl diphosphate |
? |
4.2.3.126 | (2E,6E)-farnesyl diphosphate |
- |
Coprinopsis cinerea ATCC MYA-4618 |
gamma-muurolene + diphosphate |
- |
? |
4.2.3.126 | more |
product profiling by GC-MS analysis, overview. alpha-Muurolene is the major terpenoid compound detected in Cop3 cultures, accounting for about 30% of the total sesquiterpenes detected. Significant amounts of beta-elemene, gamma-muurolene, germacrene D, and delta-cadinene are synthesized in the headspace of Cop3 cultures |
Coprinopsis cinerea |
? |
- |
? |
4.2.3.126 | more |
seven different sesquiterpenes products, wild-type Cop3 also shows alpha-muurolene synthase activity, EC 4.2.3.125, and produces 30% alpha-muurolene and 35% gemacrene A, product of germacrene A synthase, EC 4.2.3.23, of total products from (2E,6E)-farnesyl diphosphate, product profiling by GC-MS analysis, overview |
Coprinopsis cinerea |
? |
- |
? |
4.2.3.126 | more |
product profiling by GC-MS analysis, overview. alpha-Muurolene is the major terpenoid compound detected in Cop3 cultures, accounting for about 30% of the total sesquiterpenes detected. Significant amounts of beta-elemene, gamma-muurolene, germacrene D, and delta-cadinene are synthesized in the headspace of Cop3 cultures |
Coprinopsis cinerea ATCC MYA-4618 |
? |
- |
? |