EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   4.2.1.92 | (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid |
poor substrate |
Homo sapiens |
(8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + H2O |
- |
? |
| 4.2.1.92 | (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid |
intramolecular oxygenation with retention of the configuration of the carbon atom hydroxylated |
Gracilariopsis lemaneiformis |
(8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + H2O |
- |
? |
| 4.2.1.92 | (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid |
- |
Homo sapiens |
(10R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,8Z,14Z)-trienoic acid + (8R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + H2O |
the former being a isomer of hepoxilin A3, ration of products is 2:1 |
? |
| 4.2.1.92 | (13R)-hydroperoxylinolenic acid |
the G316A mutant converts (13R)-hydroperoxylinolenic acid to 13-ketolinolenic acid (with an apparent Km of 0.01 mM) and to epoxyalcohols viz. erythro- and threo-11-hydroxy-(12R,13R)-epoxy-(9Z,15Z)-octadecadienoic acids and one of the corresponding cis-epoxides as major products |
Gaeumannomyces graminis |
13-ketolinolenic acid + threo-11-hydroxy-(12R,13R)-epoxy-(9Z,15Z)-octadecadienoic acid + erythro-11-hydroxy-(12R,13R)-epoxy-(9Z,15Z)-octadecadienoic acid |
- |
? |
| 4.2.1.92 | (13S)-hydroperoxy-(9Z,11E)-octadecadienoic acid |
- |
Zea mays |
(12S,13S)-oxido-(9Z,11)-octadecadienoic acid + H2O |
- |
? |
| 4.2.1.92 | (13S)-hydroperoxy-(9Z,11E)-octadecadienoic acid |
- |
Saprolegnia parasitica |
(12S,13S)-oxido-(9Z,11)-octadecadienoic acid + H2O |
- |
? |
| 4.2.1.92 | (13S)-hydroperoxy-(9Z,11E)-octadecadienoic acid |
- |
Arabidopsis thaliana |
(12S,13S)-oxido-(9Z,11)-octadecadienoic acid + H2O |
- |
? |
| 4.2.1.92 | (13S)-hydroperoxy-(9Z,11E)-octadecadienoic acid |
- |
Passiflora edulis |
(12S,13S)-oxido-(9Z,11)-octadecadienoic acid + H2O |
- |
? |
| 4.2.1.92 | (13S)-hydroperoxy-(9Z,11E)-octadecadienoic acid |
- |
Solanum melongena |
(12S,13S)-oxido-(9Z,11)-octadecadienoic acid + H2O |
products are: 13-hydroxy-12-oxo-cis-9-octadecenoic acid + small amounts of the gamma ketol |
? |
| 4.2.1.92 | (13S)-hydroperoxy-(9Z,11E)-octadecadienoic acid |
- |
Zea mays |
(12S,13S)-oxido-(9Z,11)-octadecadienoic acid + H2O |
spontaneous hydrolysis to 12-keto-13-hydroxy-(9Z)-octadecenoic acid (72% 13(R) and 28% 13(S)) |
? |
