EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    4.2.1.36 | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate |
- |
Candida albicans |
(Z)-but-1-ene-1,2,4-tricarboxylate + H2O |
- |
? |
| 4.2.1.36 | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate |
- |
Methanocaldococcus jannaschii |
(Z)-but-1-ene-1,2,4-tricarboxylate + H2O |
- |
r |
| 4.2.1.36 | (R)-homocitrate |
- |
Candida albicans |
? |
- |
? |
| 4.2.1.36 | (Z)-but-1-ene-1,2,4-tricarboxylate + H2O |
i.e. cis-homoaconitate, three different stereoisomeric substrate types, cis-homo1-aconitate, cis-homo2-aconitate, and cis-homo3-aconitate, in the reaction, overview |
Methanocaldococcus jannaschii |
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate |
i.e. homoisocitrate, Arg26 of MJ1271 plays a key role in homoaconitate substrate recognition, while discriminating against the hydrophobic methyl or isopropyl gamma-chains of citraconate and 3-isopropylmalate. Catalytic Ser67 and Arg69 residues in the IMPI small subunit MJ1277 model are equivalent to Ser65 and Arg67 in MJ1271, but residues Val28-Tyr29 replace the polar Arg26-Thr27 residues in the flexible loop region between alpha2 and alpha3 |
r |
| 4.2.1.36 | (Z)-but-1-ene-1,2,4-tricarboxylic acid |
- |
Methanocaldococcus jannaschii |
? |
- |
? |
| 4.2.1.36 | (Z)-hex-1-ene-1,2,6-tricarboxylate |
- |
Methanocaldococcus jannaschii |
? |
- |
? |
| 4.2.1.36 | (Z)-pent-1-ene-1,2,5-tricarboxylate |
- |
Methanocaldococcus jannaschii |
? |
- |
? |
| 4.2.1.36 | 2-Hydroxy-3-carboxyadipate |
enzyme of the lysine biosynthetic pathway |
Schizosaccharomyces pombe |
? |
- |
? |
| 4.2.1.36 | 2-Hydroxy-3-carboxyadipate |
enzyme is involved in the L-Lys biosynthesis via 2-aminoadipate pathway |
Saccharomyces cerevisiae |
? |
- |
? |
| 4.2.1.36 | 2-Hydroxy-3-carboxyadipate |
enzyme is involved in the L-Lys biosynthesis via 2-aminoadipate pathway |
Aspergillus nidulans |
? |
- |
? |
