EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
  4.2.1.137 | beta-hexaprene |
substrate specificity, overview. Enzymatic cyclization of head-to-tail acyclic triterpene beta-hexaprene, a natural product isolated from Bacillus clausii, by tetraprenyl-beta-curcumene cyclase from Bacillus subtilis results in the formation of two unnatural pentacyclic triterpenes. The enzyme can be used to construct the 6/6/6/6/6-fused pentacyclic scaffold in vitro, suggesting that the active site cavity of the enzyme has sufficient space to accommodate this unnatural pentacyclic scaffold |
Bacillus subtilis |
? |
- |
? |
| 4.2.1.137 | beta-hexaprene |
substrate specificity, overview. Enzymatic cyclization of head-to-tail acyclic triterpene beta-hexaprene, a natural product isolated from Bacillus clausii, by tetraprenyl-beta-curcumene cyclase from Bacillus subtilis results in the formation of two unnatural pentacyclic triterpenes. The enzyme can be used to construct the 6/6/6/6/6-fused pentacyclic scaffold in vitro, suggesting that the active site cavity of the enzyme has sufficient space to accommodate this unnatural pentacyclic scaffold |
Priestia megaterium |
? |
- |
? |
| 4.2.1.137 | more |
it is demonstrated that a tetraprenyl-beta-curcumene cyclase also cyclizes a tail-to-tail type of linear squalene into a bicyclic triterpenol, 8alpha-hydroxypolypoda-13,17,21-triene |
Priestia megaterium |
? |
- |
? |
| 4.2.1.137 | more |
the enzyme forms tetracyclic terpenoid scaffold from tetraprenyl-beta-curcumene in vivo |
Bacillus subtilis |
? |
- |
? |
| 4.2.1.137 | more |
the enzyme forms tetracyclic terpenoid scaffold from tetraprenyl-beta-curcumene in vivo |
Priestia megaterium |
? |
- |
? |
| 4.2.1.137 | tetraprenyl-alpha-curcumene + H2O |
- |
Bacillus subtilis |
(1R,2R,4aS,4bR,6aS,10aS,10bR,12aS)-2,4b,7,7,10a,12a-hexamethyl-1-[(3R)-3-(4-methylphenyl)butyl]octadecahydrochrysen-2-ol |
- |
? |
| 4.2.1.137 | tetraprenyl-alpha-curcumene + H2O |
- |
Bacillus subtilis |
(1R,2R,4aS,4bR,6aS,10aS,10bR,12aS)-2,4b,7,7,10a,12a-hexamethyl-1-[(3R)-3-(4-methylphenyl)butyl]octadecahydrochrysen-2-ol |
the product is further converted by nonenzymatic autoxidation and thermal dehydration, overview |
? |
| 4.2.1.137 | tetraprenyl-alpha-curcumene + H2O |
- |
Bacillus subtilis 168 |
(1R,2R,4aS,4bR,6aS,10aS,10bR,12aS)-2,4b,7,7,10a,12a-hexamethyl-1-[(3R)-3-(4-methylphenyl)butyl]octadecahydrochrysen-2-ol |
- |
? |
| 4.2.1.137 | tetraprenyl-alpha-curcumene + H2O |
- |
Bacillus subtilis 168 |
(1R,2R,4aS,4bR,6aS,10aS,10bR,12aS)-2,4b,7,7,10a,12a-hexamethyl-1-[(3R)-3-(4-methylphenyl)butyl]octadecahydrochrysen-2-ol |
the product is further converted by nonenzymatic autoxidation and thermal dehydration, overview |
? |
| 4.2.1.137 | tetraprenyl-beta-curcumene + H2O |
- |
Bacillus subtilis |
baciterpenol A |
- |
? |
