EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
  3.6.1.70 | Gppp-BODIPY + H2O |
- |
Homo sapiens |
? |
- |
? |
| 3.6.1.70 | guanosine-5'-diphospho-5'-[DNA] + H2O |
substrate 12-mer Gpp-DNA strand |
Schizosaccharomyces pombe |
phospho-5'-[DNA] + GMP |
- |
? |
| 3.6.1.70 | guanosine-5'-diphospho-5'-[DNA] + H2O |
substrate 12-mer Gpp-DNA strand |
Schizosaccharomyces pombe 972 |
phospho-5'-[DNA] + GMP |
- |
? |
| 3.6.1.70 | more |
aprataxin additionally is a DNA 3'-de-capping enzyme, converting DNAppG to DNA3'p and GMP, reaction of EC 3.1.12.2. Aprataxin hydrolyzes inosine and 6-O-methylguanosine caps, but not adeoxyguanosine cap |
Schizosaccharomyces pombe |
? |
- |
? |
| 3.6.1.70 | more |
aprataxin possesses an active-site-dependent AMP-lysine and GMP-lysine hydrolase activity that depends additionally on the zinc finger for protein stability and on the forkhead associated domain for enzymatic activity. Aprataxin also shows adenosine-5'-diphospho-5'-[DNA] diphosphatase activity, reaction of EC 3.1.11.7 |
Homo sapiens |
? |
- |
? |
| 3.6.1.70 | more |
aprataxin additionally is a DNA 3'-de-capping enzyme, converting DNAppG to DNA3'p and GMP, reaction of EC 3.1.12.2. Aprataxin hydrolyzes inosine and 6-O-methylguanosine caps, but not adeoxyguanosine cap |
Schizosaccharomyces pombe ATCC 24843 |
? |
- |
? |
