EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
  3.6.1.58 | 2-hydroxy-dADP + H2O |
- |
Homo sapiens |
2-hydroxy-dAMP + phosphate |
- |
? |
| 3.6.1.58 | 2-hydroxy-dADP + H2O |
kcat/KM is 15% of the wild-type value |
Homo sapiens |
2-hydroxy-dAMP + phosphate |
- |
? |
| 3.6.1.58 | 5-formyl-dUDP + H2O |
kcat/KM is 30% of the wild-type value |
Homo sapiens |
5-formyl-dUMP + phosphate |
- |
? |
| 3.6.1.58 | 8-hydroxy-dADP + H2O |
- |
Homo sapiens |
8-hydroxy-dAMP + phosphate |
- |
? |
| 3.6.1.58 | 8-oxo-dADP + H2O |
8-oxo-dADP is hydrolyzed slightly more efficiently than 8-oxo-dGDP |
Homo sapiens |
8-oxo-dAMP + phosphate |
- |
? |
| 3.6.1.58 | 8-oxo-dGDP + H2O |
- |
Caenorhabditis elegans |
8-oxo-dGMP + phosphate |
- |
? |
| 3.6.1.58 | 8-oxo-dGDP + H2O |
specific substrate |
Homo sapiens |
8-oxo-dGMP + phosphate |
- |
? |
| 3.6.1.58 | 8-oxo-dGDP + H2O |
NUDT5 might have a much greater role than MTH1 in preventing the occurrence of mutations that are caused by the misincorporation of 8-oxoguanine in human cells. NUDT5 has another role in promoting the MTH1 reaction, in removing its inhibitor, 8-oxo-dGDP |
Homo sapiens |
8-oxo-dGMP + phosphate |
- |
? |
| 3.6.1.58 | 8-oxo-dGDP + H2O |
8-oxo-dGDP is a specific substrate for the NUDT5 protein |
Homo sapiens |
8-oxo-dGMP + phosphate |
- |
? |
| 3.6.1.58 | 8-oxo-dGDP + H2O |
ADP-ribose is a better substrate for NUDT5 compared with oxidized guanine nucleotides |
Homo sapiens |
8-oxo-dGMP + phosphate |
- |
? |
