EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.5.1.108 | more |
catalyses the second step of lipid A biosynthesis in Gram-negative bacteria |
Escherichia coli |
? |
- |
? |
3.5.1.108 | more |
catalyzes the second step in the biosynthesis of lipid A |
Escherichia coli |
? |
- |
? |
3.5.1.108 | more |
catalyzes the second step of lipid A biosynthesis in Gram negative bacteria |
Escherichia coli |
? |
- |
? |
3.5.1.108 | more |
analysis of recognition of substrates and products by the enzyme, phosphate binding is stabilized by the catalytic Zn2+ and an extensive network of hydrogen bonds to key active site residues and myr-UDP-GlcN, overview |
Escherichia coli |
? |
- |
? |
3.5.1.108 | more |
catalyzes the second step in the biosynthesis of lipid A |
Escherichia coli D22 |
? |
- |
? |
3.5.1.108 | UDP-(2-acetamino)-2-deoxy-3-O-[2-(hexylamino)-1-methyl-2-oxoethyl]-D-glucopyranose + H2O |
a homogenous fluorescence-based assay is developed that uses UDP3-O-(N-hexyl-propionamide)-N-acetylglucosamine as a surrogate substrate. This surrogate can be prepared from commercially available UDP-GlcNAc by enzymatic conversion to UDP-MurNAc, which is then chemically coupled to n-hexylamine. Following the LpxC reaction, the free amine of the deacetylation product can be derivatized by fluorescamine, thus generating a fluorescent signal |
Escherichia coli |
UDP-2-amino-2-deoxy-3-O-[2-(hexylamino)-1-methyl-2-oxoethyl]-D-glucopyranose + acetate |
- |
? |
3.5.1.108 | UDP-3-((R)-3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine + H2O |
- |
Escherichia coli |
UDP-3-((R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + acetate |
- |
? |
3.5.1.108 | UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O |
- |
Escherichia coli |
UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate |
- |
? |
3.5.1.108 | UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O |
- |
Pseudomonas aeruginosa |
UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate |
- |
? |
3.5.1.108 | UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine + H2O |
- |
Aquifex aeolicus |
UDP-3-O-((R)-3-hydroxymyristoyl)-D-glucosamine + acetate |
- |
? |