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EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
3.4.23.48
(DABCYL)-Arg-Arg-Ile-Asn-Arg-Glu-(EDANS)-NH2 + H2O
-
Yersinia pestis subsp. microtus
(DABCYL)-Arg + Arg-Ile-Asn-Arg-Glu-(EDANS)-NH2
-
?
3.4.23.48
(DABCYL)-Arg-Arg-Ile-Asn-Arg-Glu-(EDANS)-NH2 + H2O
-
Yersinia pestis subsp. pestis
(DABCYL)-Arg + Arg-Ile-Asn-Arg-Glu-(EDANS)-NH2
-
?
3.4.23.48
(DABCYL)-Arg-Arg-Ile-Asn-Arg-Glu-(EDANS)-NH2 + H2O
-
Yersinia pestis subsp. microtus 91001
(DABCYL)-Arg + Arg-Ile-Asn-Arg-Glu-(EDANS)-NH2
-
?
3.4.23.48
alpha2-antiplasmin + H2O
inactivation
Yersinia pestis
?
-
?
3.4.23.48
alpha2-antiplasmin + H2O
Pla inactivates the main physiologic inhibitor of plasmin
Yersinia pestis
?
-
?
3.4.23.48
alpha2-antiplasmin + H2O
Pla inactivates alpha2-antiplasmin
Yersinia pestis
?
-
?
3.4.23.48
alpha2-antiplasmin + H2O
a serpin
Yersinia pestis
?
-
?
3.4.23.48
alpha2-antiplasmin + H2O
alpha2AP is the main inhibitor of free plasmin in the circulation. Pla cleaves and inactivates alpha2AP by a single, rapid cut. It appears likely that the R376-M377 bait peptide bond is targeted by Pla
Yersinia pestis
?
-
?
3.4.23.48
C3 protein of complement system + H2O
-
Yersinia pestis
fragments of C3 protein of complement system
-
?
3.4.23.48
complement C3 + H2O
Pla proteolyzes complement C3 which may amiliorate the host inflammatory response by abolishing its chemoattractant properties
Yersinia pestis
?
-
?
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