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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.46((7-methoxycoumarin-4-yl)acetyl)-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(2,4-dinitrophenyl) + H2O i.e. FS-2, cleavage occurs at Leu-Asp bond Homo sapiens ((7-methoxycoumarin-4-yl)acetyl)-Ser-Glu-Val-Asn-Leu + Asp-Ala-Glu-Phe-Lys(2,4-dinitrophenyl) - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.46((7-methoxycoumarin-4-yl)acetyl)-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(2,4-dinitrophenyl) + H2O MCA, cleavage product measured by fluorescence assay, significant increases in beta-secretase activity to varying degrees in Alzheimer disease cases identified, increase not immediately correlated with levels of BACE1, differences between BACE1 and BACE2 analyzed Homo sapiens ((7-methoxycoumarin-4-yl)acetyl)-Ser-Glu-Val-Asn-Leu + Asp-Ala-Glu-Phe-Lys(2,4-dinitrophenyl) - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.46((7-methoxycoumarin-4-yl)acetyl)-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(2,4-dinitrophenyl)-Arg-Arg-NH2 + H2O synthesis, structure and potencies of beta-secretase BACE1 inhibitors optimized, effects of P4 modification on BACE1 inhibitory activity analyzed Homo sapiens ((7-methoxycoumarin-4-yl)acetyl)-Ser-Glu-Val-Asn-Leu + Asp-Ala-Glu-Phe-Lys(2,4-dinitrophenyl)-Arg-Arg-NH2 - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.46(7-methoxycoumarin-4-yl)-acetyl-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys-(2,4-dinitrophenyl)-Arg-Arg-NH2 + H2O - Rattus norvegicus ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.46(7-methoxycoumarin-4-yl)acetyl-L-Ser-L-Glu-L-Val-L-Asn-L-Leu-L-Asp-L-Ala-L-Glu-L-Phe-L-Lys-dinitrophenyl + H2O - Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.467-amido-4-methylcoumarin-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-(Lys-2,4-dinitrophenyl)-OH + H2O - Mus musculus ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.467-amido-4-methylcoumarin-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-(Lys-2,4-dinitrophenyl)-OH + H2O - Mus musculus ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.467-amido-4-methylcoumarin-SEVNLDAEFRK-(2,4-dinitrophenyl)-RR-NH2 + H2O - Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.467-methoxycoumarin-4-yl-acetyl-SEVNLDAEFR-(2,4-dinitrophenyl)K-RR + H2O - Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.467-methoxycoumarin-4-yl-SEVNLDAEFK-2,4-dinitrophenyl-RR + H2O - Homo sapiens ? - ?
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