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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.45(MCA)Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Lys(DNP) + H2O synthetic peptide substrate based on the beta-secretase cleavage site of wild-type APP Homo sapiens (MCA)Glu-Val-Lys-Met + Asp-Ala-Glu-Phe-Lys(DNP) - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.45amyloid precursor protein + H2O the enzyme cleaves amyloid precursor protein within the Abeta domain, particularly at the zeta-site (Phe20) to produce fragment C80 and prevents Abeta generation Mus musculus ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.45amyloid precursor protein + H2O - Homo sapiens fragments of amyloid precursor protein - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.45amyloid precursor protein + H2O - Rattus norvegicus fragments of amyloid precursor protein - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.45amyloid precursor protein + H2O able to cleave the beta-site but preferential cleavage of amyloid precursor protein (APP) downstream of the alpha-site of A-beta (after Phe19, theta-site), not involved in the Alzheimer’s disease pathogenesis in Down syndrome patients, able to reduce A-beta formation when expressed in primary neurons expressing the Swedish mutant of APP Homo sapiens fragments of amyloid precursor protein - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.45amyloid precursor protein + H2O can cleave the amyloid precursor protein (APP) at the N terminal Asp-1 position of A-beta, preferential cleavage within the A-beta region at Phe19 or Phe20, enzyme function is not consistent with a requirement and function of BACE1 as a beta-secretase in the brain, may act antagonistically to BACE1 Homo sapiens fragments of amyloid precursor protein soluble ectodomain (sAPPb),and a membrane-bound APP C-terminal fragment of 99 amino acids ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.45amyloid precursor protein + H2O cleavage at the beta site of amyloid precursor protein but preferably between Phe690 and Phe691 or Phe691 and Ala692 Homo sapiens fragments of amyloid precursor protein - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.45amyloid precursor protein + H2O cleavage at the beta-site but more effectively at a different site within A-beta, non-amyloidogenic function suggested Homo sapiens fragments of amyloid precursor protein - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.45amyloid precursor protein + H2O cleavage after Phe19 Homo sapiens fragments of amyloid precursor protein resulting N-terminal sequence is FAEDVGSN ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.23.45amyloid-alpha pecursor protein + H2O - Homo sapiens ? - ?
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