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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B72(SUMO-2)-nucleophosmin 1 conjugate + H2O - Homo sapiens SUMO-2 + nucleophosmin 1 - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B72(SUMO-2)-nucleophosmin 1 conjugate + H2O SENP3 as an essential factor for ribosome biogenesis. It is suggested that deconjugation of SUMO2 from nucleophosmin 1 (NPM1) by SENP3 is critically involved in 28S rRNA maturation Homo sapiens SUMO-2 + nucleophosmin 1 - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B72(SUMO-2)-p300 protein + H2O - Homo sapiens (SUMO-2) + p300 protein - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B72(SUMO-2)-p300 protein + H2O removing SUMO2/3 from p300 enhances its binding to HIF-1alpha. SENP3 is a redox sensor that regulates hypoxia-inducible factor-1alpha transcriptional activity under oxidative stress through the de-SUMOylation of p300 Homo sapiens (SUMO-2) + p300 protein - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B72(SUMO-2/3)-promyelocytic leukemia protein + H2O - Homo sapiens SUMO-2/3 + promyelocytic leukemia protein - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B72(SUMO-2/3)-promyelocytic leukemia protein + H2O SENP3 appears to be a key mediator in mild oxidative stress-induced cell proliferation via regulation of the SUMOylation status of promyelocytic leukemia protein. SENP3-mediated de-conjugation of SUMO2/3 from PML is responsible for accelerated cell proliferation and decreased promyelocytic leukemia bodies under mild oxidative stress Homo sapiens SUMO-2/3 + promyelocytic leukemia protein - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B72(SUMO-3)-hypoxia-inducible factor-1alpha protein + H2O SENP3 can remove SUMO3, but not SUMO1 from hypoxia-inducible factor-1alpha protein Homo sapiens SUMO-3 + hypoxia-inducible factor-1alpha protein - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B72(SUMO2)-Borealin protein + H2O - Homo sapiens SUMO2 + Borealin protein - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B72(SUMO2)-Borealin protein + H2O Borealin is dynamically modified by SUMO2/3 during mitosis Homo sapiens SUMO2 + Borealin protein - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.B72more SUMO-2/3-conjugated targets are more successfully deconjugated by SENP3 than SUMO-1-containing species Mus musculus ? - ?
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