EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.4.21.B57 | abnormal prion protein PrP(Sc) + H2O |
- |
Thermococcus kodakarensis |
? |
- |
? |
3.4.21.B57 | abnormal prion protein PrP(Sc) + H2O |
prion protein PrP(Sc) is a pathological prion protein PrP isoform. The enzyme can disrupt PrPSc to a level undetectable by Western-blot analysis |
Thermococcus kodakarensis |
? |
- |
? |
3.4.21.B57 | abnormal prion protein PrP(Sc) + H2O |
the abnormal prion protein (scrapie-associated prion protein, PrP(Sc)) is considered to be included in the group of infectious agents of transmissible spongiform encephalopathies. Although PrP(Sc) is known to be resistant toward proteolytic enzymes, Tk-subtilisin is able to degrade PrP(Sc) under extreme conditions |
Thermococcus kodakarensis |
? |
- |
? |
3.4.21.B57 | abnormal prion protein PrP(Sc) + H2O |
the prion protein PrP(Sc) is a pathological prion protein PrP isoform. The proteolytic activity of pernisine does not depend on the species of origin of the PrP used (bovine, mouse, human) |
Aeropyrum pernix |
? |
- |
? |
3.4.21.B57 | abnormal prion protein PrP(Sc) + H2O |
the prion protein PrP(Sc) is a pathological prion protein PrP isoform. The proteolytic activity of pernisine does not depend on the species of origin of the PrP used (bovine, mouse, human) |
Aeropyrum pernix DSM 11879 |
? |
- |
? |
3.4.21.B57 | azocasein + H2O |
- |
Aeropyrum pernix |
? |
- |
? |
3.4.21.B57 | azocasein + H2O |
- |
Thermococcus kodakarensis |
? |
- |
? |
3.4.21.B57 | azocasein + H2O |
- |
Aeropyrum pernix DSM 11879 |
? |
- |
? |
3.4.21.B57 | Bovine serum albumin + H2O |
among the proteins tested, casein shows the highest degree of susceptibility with 100% of hydrolysis, while in the case of hemoglobin, ovalbumin, and bovine serum albumin it was about 50% |
Aeropyrum pernix |
? |
- |
? |
3.4.21.B57 | Bovine serum albumin + H2O |
among the proteins tested, casein shows the highest degree of susceptibility with 100% of hydrolysis, while in the case of hemoglobin, ovalbumin, and bovine serum albumin it was about 50% |
Aeropyrum pernix DSM 11879 |
? |
- |
? |