EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.4.21.69 | active factor Va + H2O |
proteolytic inactivation |
Homo sapiens |
inactive factor V + ? |
- |
? |
3.4.21.69 | active factor Va + H2O |
proteolytic inactivation of the cofactor in the prothrombinase complex |
Homo sapiens |
inactive factor V + ? |
- |
? |
3.4.21.69 | active factor Va + H2O |
proteolytic inactivation, cleavage of the heavy chain at Arg506, Arg306, and Arg679, factor Xa protects factor Va from inactivation by APC, interaction of factor Va and APC at residues 311-325 of the substrate |
Homo sapiens |
inactive factor V + ? |
- |
? |
3.4.21.69 | active factor Va + H2O |
proteolytic inactivation, the autolysis loop of APC represents the active site, active site topology, the loop plays a critical role in restricting both the specificity and spatial environment of the active-site groove of APC, overview |
Homo sapiens |
inactive factor V + ? |
- |
? |
3.4.21.69 | active factor Va + H2O |
proteolytic inactivation |
Homo sapiens |
inactive factor V + domain B |
- |
? |
3.4.21.69 | active factor Va + H2O |
activated protein C inhibits the procoagulant function of activated factor V through proteolytic cleavage |
Homo sapiens |
inactive factor V + domain B |
- |
? |
3.4.21.69 | active factor Va + H2O |
proteolytic inactivation requires interactions with both EPCR and PAR-1 |
Homo sapiens |
inactive factor V + domain B |
- |
? |
3.4.21.69 | active factor Va + H2O |
proteolytic inactivation, cleavage at Arg306 and Arg506 |
Homo sapiens |
inactive factor V + domain B |
- |
? |
3.4.21.69 | active factor Va + H2O |
proteolytic inactivation, cleavages at Arg306, Arg506, and Arg679, the cleavage at Arg506 is kinetically favored but protected by factor Xa |
Homo sapiens |
inactive factor V + domain B |
- |
? |
3.4.21.69 | active factor Va + H2O |
proteolytic inactivation, the basic residues of two surface loops including those on 39 and the Ca2+-binding 70-80 loops constitute interactive sites for both factors Va and VIIIa, thereby mediating the interaction of APC specifically with these procoagulant cofactors |
Homo sapiens |
inactive factor V + domain B |
- |
? |