EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.21.115 | more |
acyl-enzyme complex for intermolecular self-cleavage reaction determined by crystallization, conserved overall structure of VP4 determined despite of only 20% sequence identity between different VP4 proteins |
infectious pancreatic necrosis virus |
? |
- |
? |
| 3.4.21.115 | more |
cleavage sites of the MABV polyprotein at the pVP2-VP4 junction determined, VP4 protease activity determined, expression patterns of pVP2, VP4 and VP3 in four infected cell lines shown, VP4 protease activity determined |
marine birnavirus |
? |
- |
? |
| 3.4.21.115 | NH2-pVP2-X-VP4-VP3-COOH + H2O |
VP4 is encoded as part of the 1114-residue long segment A polyprotein NH2-pVP2-X-VP4-VP3-COOH. It cleaves after amino acid residue positions 512, 618, and 830 to yield capsid precursor protein pVP2, peptide X, VP4 itself, and ribonucleoprotein VP3. Additional cleavage sites were found at the C-terminal side of amino acids 451, 492, and 499 within the pVP2 region |
Tellina virus 1 |
pVP2 + peptide X + VP4 + VP3 |
- |
? |
| 3.4.21.115 | polyprotein of BSNV + H2O |
- |
Infectious bursal disease virus |
pVP2 + VP3 + VP4 |
- |
? |
| 3.4.21.115 | polyprotein of BSNV + H2O |
- |
infectious pancreatic necrosis virus |
pVP2 + VP3 + VP4 |
- |
? |
| 3.4.21.115 | polyprotein of BSNV + H2O |
- |
Blotched snakehead virus |
pVP2 + VP3 + VP4 |
- |
? |
| 3.4.21.115 | polyprotein of BSNV + H2O |
- |
Drosophila X virus |
pVP2 + VP3 + VP4 |
- |
? |
| 3.4.21.115 | polyprotein of IPNV + H2O |
cleaves at the (Ser/Thr)-X-Ala-/-(Ser/Ala)-Gly motif, -/- = cleavage site |
infectious pancreatic necrosis virus |
pVP2 + VP3 + VP4 |
- |
? |
| 3.4.21.115 | polyprotein of IPNV + H2O |
the viral NS protease is active and cleaves the polyprotein when it is expressed in Escherichia coli |
infectious pancreatic necrosis virus |
pVP2 + VP3 + VP4 |
- |
? |
