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EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
3.4.21.107
ADAM9 + H2O
54% cleavage
Homo sapiens
?
-
?
3.4.21.107
aggrecan + H2O
the HtrA1-specific cleavage site is VQTV3562357TWPD within the interglobular domain of aggrecan
Homo sapiens
aggrecan fragments
-
?
3.4.21.107
alpha-casein + H2O
-
Escherichia coli
?
-
?
3.4.21.107
alpha-casein + H2O
weaker substrate than beta-casein
Escherichia coli
?
-
?
3.4.21.107
alpha-lactalbumin + H2O
-
Thermotoga maritima
?
-
?
3.4.21.107
alpha-lactalbumin + H2O
acts on the fully unfolded protein but not on the native form
Escherichia coli
?
-
?
3.4.21.107
alpha-lactalbumin + H2O
only when incubated in the presence of 20 mM dithiothreitol, which reduces the structural disulfide bonds and unfold the protein, and above 34°C, is CtHtrA able to proteolyse alpha-lactalbumin
Chlamydia trachomatis
?
-
?
3.4.21.107
alpha-tubulin + H2O
-
Homo sapiens
?
-
?
3.4.21.107
alpha2-macroglobulin + H2O
55% cleavage
Homo sapiens
?
-
?
3.4.21.107
amylase MalS + H2O
-
Rickettsia sp.
?
-
?
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