EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.17.21 | amyloid-beta + H2O |
the enzyme has two distinctive binding sites for two different substrates. Amyloid-beta degradation occurs through S1 pocket but not through S1' pocket responsible for hydrolysis of N-acetyl-L-aspartyl-L-glutamate. Pre-incubation with N-acetyl-L-aspartyl-L-glutamate and amyloid-beta does not affect amyloid-beta degradation and hydrolysis of N-acetyl-L-aspartyl-L-glutamate, respectively |
Homo sapiens |
? |
- |
? |
| 3.4.17.21 | folyl-(gamma-L-glutamic acid)2 + H2O |
- |
Homo sapiens |
folyl-gamma-L-glutamic acid + L-glutamate |
- |
? |
| 3.4.17.21 | folyl-(gamma-L-glutamic acid)3 + H2O |
- |
Homo sapiens |
folyl-(gamma-L-glutamic acid)2 + L-glutamate |
- |
? |
| 3.4.17.21 | folyl-(gamma-L-glutamic acid)4 + H2O |
- |
Homo sapiens |
folyl-(gamma-L-glutamic acid)3 + L-glutamate |
- |
? |
| 3.4.17.21 | folyl-gamma-L-glutamic acid + H2O |
- |
Homo sapiens |
folate + L-glutamate |
- |
? |
| 3.4.17.21 | folyl-poly-gamma-glutamate + H2O |
cleavage of the C-terminal glutamate |
Homo sapiens |
? |
- |
? |
| 3.4.17.21 | gamma-L-Glu-L-Glu + H2O |
- |
Rattus norvegicus |
L-Glu + L-Glu |
- |
? |
| 3.4.17.21 | L-Asp-L-Glu + H2O |
- |
Rattus norvegicus |
L-Asp + L-Glu |
- |
? |
| 3.4.17.21 | L-Glu-L-Glu + H2O |
- |
Rattus norvegicus |
L-Glu + L-Glu |
- |
? |
| 3.4.17.21 | methotrexate triglutamate + H2O |
- |
Homo sapiens |
L-Glu + methotrexate |
- |
? |
