EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.8.2.36 | 3'-phosphoadenylyl sulfate + desulfo-A47934 |
the enzyme catalyzes the final step in the biosynthesis of the glycopeptide antibiotic A47934 |
Streptomyces toyocaensis |
adenosine 3',5'-bisphosphate + A47934 |
i.e. LY 154989 |
? |
2.8.2.36 | 3'-phosphoadenylyl sulfate + desulfo-A47934 |
100-fold preference for desulfo-A47934 over teicoplanin |
Streptomyces toyocaensis |
adenosine 3',5'-bisphosphate + A47934 |
i.e. LY 154989 |
? |
2.8.2.36 | 3'-phosphoadenylyl sulfate + teicoplanin |
the sulfated residue of sulfo-teicoplanin is not unambiguously identified. Based on the precedent with the A47934 fragmentation, it is concluded that His6-StaL preferentially sulfates the glycopeptide antibiotics on the N-terminal 4-hydroxy-L-phenylglycine residue |
Streptomyces toyocaensis |
adenosine 3',5'-bisphosphate + sulfo-teicoplanin |
- |
? |
2.8.2.36 | 3'-phosphoadenylyl sulfate + teicoplanin aglycone |
the sulfated residue of sulfo-teicoplanin is not unambiguously identified. Based on the precedent with the A47934 fragmentation, it is concluded that His6-StaL preferentially sulfates the glycopeptide antibiotics on the N-terminal 4-hydroxy-L-phenylglycine residue |
Streptomyces toyocaensis |
adenosine 3',5'-bisphosphate + sulfoteicoplanin aglycone |
- |
? |