EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.7.8.28 | lactyl-2-diphospho-5'-adenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin |
catalysis does not appear to proceed via a covalent intermediate |
Methanocaldococcus jannaschii |
adenosine 5'-phosphate + coenzyme F420-0 |
coenzyme F420-0 is coenzyme F420 without glutamic acid |
? |
| 2.7.8.28 | lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin |
the reaction is the fourth step in the biosynthesis of coenzyme F420 |
Methanocaldococcus jannaschii |
guanosine 5'-phosphate + coenzyme F420-0 |
coenzyme F420-0 is coenzyme F420 without glutamic acid |
? |
| 2.7.8.28 | lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin |
the reaction is the fourth step in the biosynthesis of coenzyme F420 |
Methanosarcina mazei |
guanosine 5'-phosphate + coenzyme F420-0 |
coenzyme F420-0 is coenzyme F420 without glutamic acid |
? |
| 2.7.8.28 | lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin |
catalysis does not appear to proceed via a covalent intermediate. Lactyl-2-diphospho-5'-guanosine is the preferred substrate. The substrate binding site of CofD is very specific for 7,8-didemethyl-8-hydroxy-5-deazariboflavin |
Methanocaldococcus jannaschii |
guanosine 5'-phosphate + coenzyme F420-0 |
coenzyme F420-0 is coenzyme F420 without glutamic acid |
? |
| 2.7.8.28 | more |
to a lesser extent CofD also catalyzes a number of additional reactions that include the formation of 7,8-didemethyl-8-hydroxy-5-deazariboflavin 5'-phosphate, when the enzyme is incubated with 7,8-didemethyl-8-hydroxy-5-deazariboflavin and GDP, GTP, diphosphate, or tripolyphosphate, and the hydrolysis of F420-0 (F420 without glutamic acids) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin |
Methanocaldococcus jannaschii |
? |
- |
? |
