EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.7.7.81 | CTP + 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid |
CMP-pseudaminic acid biosynthesis. Helicobacter pylori, heavily modifies its flagellin with pseudaminic acid, a modification that influences pathogenesis through bacterial adhesion, invasion, and immune evasion |
Helicobacter pylori |
diphosphate + CMP-5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid |
- |
? |
2.7.7.81 | CTP + 5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid |
when all six CMP-pseudaminic acid biosynthetic enzymes (PseB, PseC, PseH, PseG, PseI, PseF) are combined in a reaction with UDP-N-acetylglucosamine, synthesis of VII is successful CMP-pseudaminic acid. Combining the first five enzymes (PseB, PseC, PseH, PseG, PseI) in a one-pot reaction results in 100% conversion of UDP-N-acetylglucosamine to pseudaminic acid after 20 h |
Helicobacter pylori |
diphosphate + CMP-5,7-bis(acetylamino)-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid |
- |
? |
2.7.7.81 | CTP + 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid |
- |
Helicobacter pylori |
diphosphate + CMP-5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid |
- |
? |
2.7.7.81 | CTP + 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid |
- |
Helicobacter pylori P12 |
diphosphate + CMP-5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-2-nonulopyranosonic acid |
- |
? |