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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.16ATP + a G protein-coupled receptor the GRKs are important in the cardiovascular system, the major G protein-coupled receptor regulatory pathway involves phosphorylation of activated receptors by GRKs, followed by binding of arrestin proteins, which prevent receptors from activating downstream heterotrimeric G protein pathways while allowing activation of arrestin-dependent signaling pathways, general mechanisms of GRK-arrestin regulation, overview, physiological functions and potential pathophysiological roles of GRKs and arrestins in human disorders, overview Mus musculus ADP + a phosphorylated G protein-coupled receptor - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.16ATP + a G protein-coupled receptor the GRKs are important in the cardiovascular system, the major G protein-coupled receptor regulatory pathway involves phosphorylation of activated receptors by GRKs, followed by binding of arrestin proteins, which prevent receptors from activating downstream heterotrimeric G protein pathways while allowing activation of arrestin-dependent signaling pathways, general mechanisms of GRK-arrestin regulation, overview, physiological functions and potential pathophysiological roles of GRKs and arrestins in human disorders, overview Homo sapiens ADP + a phosphorylated G protein-coupled receptor - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.16ATP + a G protein-coupled receptor cell surface localized receptors Mus musculus ADP + a phosphorylated G protein-coupled receptor - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.16ATP + a G protein-coupled receptor cell surface localized receptors Homo sapiens ADP + a phosphorylated G protein-coupled receptor - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.16ATP + activated form of G protein-coupled receptors - Homo sapiens ADP + phosphorylated G protein-coupled receptors - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.16ATP + alpha-synuclein GRK5 phosphorylates Ser-129 of alpha-synuclein at the plasma membrane and induces translocation of phosphorylated alpha-synuclein to the perikaryal area, GRK5 promotes alpha-linolenic acid-induced oligomerization of alpha-synuclein, alpha-synuclein phosphorylation by GRK5 plays a crucial role in the pathogenesis of sporadic Parkinson's disease, sPD Homo sapiens ADP + phosphorylated alpha-synuclein - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.16ATP + alpha-synuclein phosphorylation at Ser129 Homo sapiens ADP + phosphorylated alpha-synuclein - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.16ATP + alpha1-adrenergic receptor GRK5 is also active with alpha1-adrenergic receptors. GRK5 activity, but not GRK2 activity, toward alpha1-adrenergic receptors can lead to transactivation of the tyrosine kinase receptor for epidermal growth factor in myocytes, cf. EC 2.7.11.15 Mus musculus ADP + alpha1-adrenergic receptor phosphate - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.16ATP + ATP + G protein-coupled receptor - Mus musculus ADP + phosphorylated G protein-coupled receptor - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.11.16ATP + ATP + G protein-coupled receptor - Homo sapiens ADP + phosphorylated G protein-coupled receptor - ?
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