EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    2.4.2.54 | 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate |
- |
Archaeoglobus fulgidus |
4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate |
- |
? |
| 2.4.2.54 | 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate |
the enzyme is involved in biosynthesis of tetrahydromethanopterin, a folate analog involved in the C1 metabolism of methanogenic archaea, sulfate-reducing archaea, and methylotrophic bacteria |
Archaeoglobus fulgidus |
4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate |
- |
? |
| 2.4.2.54 | 5-phospho-alpha-D-ribose 1-diphosphate + 4-amino-3,5-dicarboxypyrazole |
- |
Streptomyces candidus |
4-amino-3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(oxophosphanyl)oxolan-2-yl]-1H-pyrazole-5-carboxylic acid + CO2 + diphosphate |
- |
? |
| 2.4.2.54 | 5-phospho-alpha-D-ribose 1-diphosphate + 4-amino-3,5-dicarboxypyrazole |
- |
Streptomyces candidus NRRL 3601 |
4-amino-3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(oxophosphanyl)oxolan-2-yl]-1H-pyrazole-5-carboxylic acid + CO2 + diphosphate |
- |
? |
| 2.4.2.54 | 5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate |
- |
Methanosarcina thermophila |
4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate |
- |
? |
| 2.4.2.54 | 5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate |
the enzyme is involved in biosynthesis of tetrahydromethanopterin, a folate analog involved in the C1 metabolism of methanogenic archaea, sulfate-reducing archaea, and methylotrophic bacteria |
Methanosarcina thermophila |
4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate |
- |
? |
| 2.4.2.54 | 5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate |
the enzyme is involved in biosynthesis of tetrahydromethanopterin, a folate analog involved in the C1 metabolism of methanogenic archaea, sulfate-reducing archaea, and methylotrophic bacteria |
Methanocaldococcus jannaschii |
4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate |
- |
? |
| 2.4.2.54 | 5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate |
ordered Bi-Ter mechanism involving binding of 5-phospho-alpha-D-ribose 1-diphosphate, then 4-aminobenzoate, followed by release of the products CO2, then 4-(beta-D-ribofuranosyl)aminobenzene-5'-phosphate, and finally diphosphate |
Methanocaldococcus jannaschii |
4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate |
- |
? |
| 2.4.2.54 | 5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate |
sequential pattern of substrate binding. An SN1-like reaction produces oxonium ion character at C-1 of 5-phospho-alpha-D-ribose 1-diphosphate which undergoes an ipso electrophilic aromatic substitution reaction at the carboxylic acid-bound carbon of 4-aminobenzoate. Decarboxylation of the resulting cyclohexadienimine intermediate leads to the formation of 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate |
Methanosarcina thermophila |
4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate |
- |
? |
| 2.4.2.54 | 5-phospho-alpha-D-ribose 1-diphosphate + 4-aminobenzoate |
- |
Methylorubrum extorquens |
4-(beta-D-ribofuranosyl)aniline 5'-phosphate + CO2 + diphosphate |
- |
? |
