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EC Number	Substrates	Commentary Substrates	Organism	Products	Commentary (Products)	Reversibility
2.4.2.43	(2Z)-3,7-dimethylocta-2,6-dien-1-yl 1-O-(4-amino-4-deoxy-alpha-L-arabinopyranosyl) phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A	-	Burkholderia cenocepacia	?	-	?
2.4.2.43	4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate + lipid IVA	-	Salmonella enterica subsp. enterica serovar Typhimurium	lipid IIA + di-trans,poly-cis-undecaprenyl phosphate	-	?
2.4.2.43	4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate + lipid IVA	-	Escherichia coli	lipid IIA + di-trans,poly-cis-undecaprenyl phosphate	-	?
2.4.2.43	4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate + lipid IVA	ArnT confers resistance to the antibiotic polymyxin in Salmonella typhimurium and Escherichia coli through the modification of lipid A, a major component of the outer surface of Gram-negative bacteria. ArnT transfers a neutral aminoarabinose moiety onto the negative phosphate groups of lipid A, reducing the surface charge of the bacteria and preventing cationic peptides such as polymyxin from electrostatically recognizing and killing the bacteria. Only small amounts of ArnT are necessary to provide resistance against polymyxin to the bacterial cell	Salmonella enterica subsp. enterica serovar Typhimurium	lipid IIA + di-trans,poly-cis-undecaprenyl phosphate	-	?
2.4.2.43	4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate + lipid IVA	the reaction is part of a enzymatic pathway by which Gram-negative bacteria acquire antibiotic resistance	Salmonella enterica subsp. enterica serovar Typhimurium	lipid IIA + di-trans,poly-cis-undecaprenyl phosphate	-	?
2.4.2.43	4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate + lipid IVA	the reaction is part of a enzymatic pathway by which Gram-negative bacteria acquire antibiotic resistance	Escherichia coli	lipid IIA + di-trans,poly-cis-undecaprenyl phosphate	-	?
2.4.2.43	4-amino-4-deoxy-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A	-	Pseudomonas aeruginosa	alpha-Kdo-(2->4)-Kdo-(2->6)-[4-P-L-Ara4N]-lipid A + ditrans,octacis-undecaprenyl phosphate	-	?
2.4.2.43	4-amino-4-deoxy-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A	-	Salmonella enterica	alpha-Kdo-(2->4)-Kdo-(2->6)-[4-P-L-Ara4N]-lipid A + ditrans,octacis-undecaprenyl phosphate	-	?
2.4.2.43	4-amino-4-deoxy-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A	-	Cupriavidus metallidurans	alpha-Kdo-(2->4)-Kdo-(2->6)-[4-P-L-Ara4N]-lipid A + ditrans,octacis-undecaprenyl phosphate	-	?
2.4.2.43	4-amino-4-deoxy-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A	-	Burkholderia cenocepacia	alpha-Kdo-(2->4)-Kdo-(2->6)-[4-P-L-Ara4N]-lipid A + ditrans,octacis-undecaprenyl phosphate	-	?

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Release 2023.1 (January 2023)