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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the reaction diagram Show all sequences 2.4.1.322dTDP-beta-L-acosamine + devancosaminyl-vancomycin - Amycolatopsis orientalis dTDP + ? - ?
Display the reaction diagram Show all sequences 2.4.1.322dTDP-beta-L-daunosamine + devancosaminyl-vancomycin - Amycolatopsis orientalis dTDP + ? - ?
Display the reaction diagram Show all sequences 2.4.1.322dTDP-beta-L-vancosamine + desvancosaminyl-vancomycin - Amycolatopsis orientalis dTDP + vancomycin - ?
Display the reaction diagram Show all sequences 2.4.1.322dTDP-beta-L-vancosamine + desvancosaminyl-vancomycin - Amycolatopsis orientalis ATCC 19795 dTDP + vancomycin - ?
Display the reaction diagram Show all sequences 2.4.1.322dTDP-beta-L-vancosamine + devancosaminyl-vancomycin natural substrate Amycolatopsis orientalis dTDP + vancomycin - ?
Display the reaction diagram Show all sequences 2.4.1.322dTDP-beta-L-vancosamine + devancosaminyl-vancomycin the enzyme catalyses the ultimate step in the biosynthesis of the antibiotic vancomycin Amycolatopsis orientalis dTDP + vancomycin - ?
Display the reaction diagram Show all sequences 2.4.1.322dTDP-beta-L-vancosamine + devancosaminyl-vancomycin dTDP-beta-L-vancosamine i.e. dTDP-3-amino-2,3,6-trideoxy-3-C-methyl-beta-L-lyxo-hexopyranose. The enzyme binds TDP in the interdomain cleft, while the aglycone acceptor binds in a deep crevice in the N-terminal domain. The two domains are interdependent in terms of substrate binding and overall structure. Asp13 is a catalytic general base, with a possible secondary role for Thr10 Amycolatopsis orientalis dTDP + vancomycin - ?
Display the reaction diagram Show all sequences 2.4.1.322more by tandem reaction of both glucosyltransferase GtfE and L-vancosaminyltransferase GtfD, amino- or deoxy hybrid disaccharide chains can be built on both teicoplanin and vancomycin aglycone scaffolds Amycolatopsis orientalis ? - ?
Display the reaction diagram Show all sequences 2.4.1.322more enzyme shows moderately relaxed donor substrate specificities for the glycosylation of its natural aglycone. It transfers 4-epi-L-vancosamine, L-daunosamine, and L-acosamine with good turnover. 2-Deoxy-L-glucose, 2-deoxy-L-rhamnose, and L-ristosamine are transferred in trace amounts, whereas for substrates containing an amino group at C-4, no product is observed Amycolatopsis orientalis ? - ?
Display the reaction diagram Show all sequences 2.4.1.322more modification of the C- or N-terminus of the vancomycin aglycon does not inhibit completion of the transfer reaction Amycolatopsis orientalis ? - ?
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