EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.4.1.27 | more |
the AGT with GT-B glycosyltransferase fold is responsible for DNA base flipping and substrate recognition, mechanism, overview |
Tequatrovirus T4 |
? |
- |
? |
2.4.1.27 | more |
the alpha-linkage forming enzyme AGT is also able to adopt the fold of a GT-B glycosyltransferase keeping the sugar donor binding mechanism typical for GT-B glycosyltransferases, but showing a unique sugar acceptor binding mode, both substrates are bound to the C-terminal domain, detailed substrate binding structures, catalytic mechanism of both enzyme types, overview |
Tequatrovirus T4 |
? |
- |
? |
2.4.1.27 | more |
enzyme shows strong preference for the glucosylation of DNA containing symmetrical 5-hydroxymethyl cytosine resiudes over hemi-5-hydroxymethyl cytosine. The enzyme is capable of saturation glucosylation on all conformations of 5-hydroxymethyl cytosine.The numbers of 5-hydroxymethyl cytosine residues on DNA can influence catalysis, especially the rate of catalysis, and hemihydroxymethylated DNA is not the preferred substrate of the enzyme |
Tequatrovirus T4 |
? |
- |
? |
2.4.1.27 | UDP-alpha-D-glucose + 5-hydroxymethylcytosine containing DNA |
- |
Tequatrovirus T4 |
UDP + beta-D-glucosyl-5-hydroxymethylcytosine containing DNA |
- |
- |
2.4.1.27 | UDP-alpha-D-glucose + 5-hydroxymethylcytosine containing DNA |
- |
Tequatrovirus T4 |
UDP + beta-D-glucosyl-5-hydroxymethylcytosine containing DNA |
- |
? |
2.4.1.27 | UDP-alpha-D-glucose + 5-hydroxymethylcytosine containing DNA |
DNA-modifying enzyme |
Tequatrovirus T4 |
UDP + beta-D-glucosyl-5-hydroxymethylcytosine containing DNA |
- |
? |
2.4.1.27 | UDP-alpha-D-glucose + 5-hydroxymethylcytosine containing DNA |
the enzyme forms part of a phage DNA protection system |
Tequatrovirus T4 |
UDP + beta-D-glucosyl-5-hydroxymethylcytosine containing DNA |
- |
? |
2.4.1.27 | UDP-alpha-D-glucose + 5-hydroxymethylcytosine containing DNA |
the enzyme is part of a system by which T-even bacteriophages glycosylate their genomic DNA in order to protect it against nuclease attack |
Tequatrovirus T4 |
UDP + beta-D-glucosyl-5-hydroxymethylcytosine containing DNA |
- |
? |
2.4.1.27 | UDP-alpha-D-glucose + 5-hydroxymethylcytosine containing DNA |
the enzyme modifies T4-DNA |
Tequatrovirus T4 |
UDP + beta-D-glucosyl-5-hydroxymethylcytosine containing DNA |
- |
? |
2.4.1.27 | UDP-alpha-D-glucose + 5-hydroxymethylcytosine-containing DNA |
- |
Tequatrovirus T4 |
UDP + beta-D-glucosyl-5-hydroxymethylcytosine-containing DNA |
- |
- |