EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.3.2.B11 | more |
no activity with beta-lactoglobulin, beta-casein, kappa-casein, alpha-casein and oxidized ribonuclease |
Saccharomyces cerevisiae |
? |
- |
? |
2.3.2.B11 | more |
in vivo calmodulin is ubiquitylated at lysine 22 |
Saccharomyces cerevisiae |
? |
- |
? |
2.3.2.B11 | more |
purified Asr1p E3 ligase, the E1 enzyme and the E2 enzyme UbcH5a are sufficient for in vitro ubiquitylation of calmodulin, requiring a function Asr1p Ring domain |
Saccharomyces cerevisiae |
? |
- |
? |
2.3.2.B11 | more |
UBE3B shows HECT E3 ubiquitin ligase activity and exhibits time-dependent auto-ubiquitylation activity |
Homo sapiens |
? |
- |
- |
2.3.2.B11 | n ATP + calmodulin + n ubiquitin |
specific function of the enzyme in the Ca2+-dependent breakdown of calmodulin in vertebrate (eukaryotic) cells |
Oryctolagus cuniculus |
? |
- |
? |
2.3.2.B11 | n ATP + calmodulin + n ubiquitin |
Ca2+-dependent ubiquitination only of free calmodulin may provide an efficient scavenging mechanism (with subsequent breakdown) for all free calmodulin in excess of that amount which can be found by the calmodulin-binding proteins in the cell |
Oryctolagus cuniculus |
? |
- |
? |
2.3.2.B11 | n ATP + calmodulin + n ubiquitin |
the activity is regulated by the binding of the second messenger Ca2+ to the substrate calmodulin, which increases the activity ca. 10fold |
Oryctolagus cuniculus |
? |
- |
? |
2.3.2.B11 | n ATP + calmodulin + n ubiquitin |
it is very probably that the ubiquitination of calmodulin belongs to the normal regulatory repertoire of the eukaryotic cell |
Oryctolagus cuniculus |
? |
- |
? |
2.3.2.B11 | n ATP + calmodulin + n ubiquitin |
monoubiquitylation strongly decreases the biological activity of calmodulin towards phosphorylase kinase by reducing its affinity approximately threefold and the maximal degree of activation approximately twofold |
Oryctolagus cuniculus |
? |
- |
? |
2.3.2.B11 | [RING-E3-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [calmodulin]-L-lysine |
- |
Oryctolagus cuniculus |
[RING-E3-ubiquitin-carrier protein]-L-cysteine + [calmodulin]-N6-ubiquitinyl-L-lysine |
- |
? |