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Results 1 - 9 of 9
EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B2516 malonyl-CoA + 28 H+ - Aloe arborescens 16 CoA + 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-2-methyl-2,3-dihydro-4H-chromen-4-one + 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-5-methyl-2,3-dihydro-4H-chromen-4-one + 16 CO2 + 16 H2O - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B258 malonyl-CoA - Aloe arborescens 8 CoA + 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-2-methyl-2,3-dihydro-4H-chromen-4-one + 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-5-methyl-2,3-dihydro-4H-chromen-4-one + 8 CO2 + H2O - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B258 malonyl-CoA - Aloe arborescens 8 CoA + 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-2-methyl-2,3-dihydro-4H-chromen-4-one + 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-5-methyl-2,3-dihydro-4H-chromen-4-one + 8 CO2 + H2O i.e. SEK4 and SEK4b ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25more the oktaketide synthase reaction is also catalyzed by chalcone synthase (EC 2.3.1.74) mutant T197G/G256L/S338V, CHS containing a double point mutation G256L/S338V not only accepts 4coumaroyl-CoA but also biosynthesizes octaketides SEK4 and 4b, exhausting eight malonyl-CoAs Aloe arborescens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25more recombinant oktaketide synthase catalyzes sequential condensations of eight molecules of malonyl-CoA to yield a 1:4 mixture of aromatic octaketides, 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-2-methyl-2,3-dihydro-4H-chromen-4-one and 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-5-methyl-2,3-dihydro-4H-chromen-4-one, which are the longest polyketides generated by the structurally simple type III polyketide synthase. Recombinant oktaketide synthase accepts acetyl-CoA, resulting from decarboxylation of malonyl-CoA, as a starter substrate Aloe arborescens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25more enzyme DynE8 makes 2, which is proposed to form the dynemicin enediyne and anthraquinone in the presence of accessory enzymes, and heptaene 1 in the presence of its native TE, DynE7. The end product is enediyne 3, synthesis pathway, overview Micromonospora chersina ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25more enzyme AaOKS, which is related to the chalcone synthase (CHS) gene family, catalyzes the formation of a linear octaketide, solely by using malonyl-CoA as a substrate. Aloesone is formed by spontaneous cyclization of a linear heptaketide chain made from seven malonyl-CoA units Aloe arborescens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25more the plant type III polyketide synthase, oktaketide synthase (OKS) forms a non-reduced linear octaketide Aloe arborescens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B25more enzyme DynE8 makes 2, which is proposed to form the dynemicin enediyne and anthraquinone in the presence of accessory enzymes, and heptaene 1 in the presence of its native TE, DynE7. The end product is enediyne 3, synthesis pathway, overview Micromonospora chersina NRRL B-24756 ? - -
Results 1 - 9 of 9