EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.3.1.B25 | 16 malonyl-CoA + 28 H+ |
- |
Aloe arborescens |
16 CoA + 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-2-methyl-2,3-dihydro-4H-chromen-4-one + 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-5-methyl-2,3-dihydro-4H-chromen-4-one + 16 CO2 + 16 H2O |
- |
? |
2.3.1.B25 | 8 malonyl-CoA |
- |
Aloe arborescens |
8 CoA + 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-2-methyl-2,3-dihydro-4H-chromen-4-one + 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-5-methyl-2,3-dihydro-4H-chromen-4-one + 8 CO2 + H2O |
- |
? |
2.3.1.B25 | 8 malonyl-CoA |
- |
Aloe arborescens |
8 CoA + 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-2-methyl-2,3-dihydro-4H-chromen-4-one + 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-5-methyl-2,3-dihydro-4H-chromen-4-one + 8 CO2 + H2O |
i.e. SEK4 and SEK4b |
? |
2.3.1.B25 | more |
the oktaketide synthase reaction is also catalyzed by chalcone synthase (EC 2.3.1.74) mutant T197G/G256L/S338V, CHS containing a double point mutation G256L/S338V not only accepts 4coumaroyl-CoA but also biosynthesizes octaketides SEK4 and 4b, exhausting eight malonyl-CoAs |
Aloe arborescens |
? |
- |
? |
2.3.1.B25 | more |
recombinant oktaketide synthase catalyzes sequential condensations of eight molecules of malonyl-CoA to yield a 1:4 mixture of aromatic octaketides, 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-2-methyl-2,3-dihydro-4H-chromen-4-one and 2,7-dihydroxy-5-[(4-hydroxy-2-oxo-2H-pyran-6-yl)methyl]-5-methyl-2,3-dihydro-4H-chromen-4-one, which are the longest polyketides generated by the structurally simple type III polyketide synthase. Recombinant oktaketide synthase accepts acetyl-CoA, resulting from decarboxylation of malonyl-CoA, as a starter substrate |
Aloe arborescens |
? |
- |
? |
2.3.1.B25 | more |
enzyme DynE8 makes 2, which is proposed to form the dynemicin enediyne and anthraquinone in the presence of accessory enzymes, and heptaene 1 in the presence of its native TE, DynE7. The end product is enediyne 3, synthesis pathway, overview |
Micromonospora chersina |
? |
- |
- |
2.3.1.B25 | more |
enzyme AaOKS, which is related to the chalcone synthase (CHS) gene family, catalyzes the formation of a linear octaketide, solely by using malonyl-CoA as a substrate. Aloesone is formed by spontaneous cyclization of a linear heptaketide chain made from seven malonyl-CoA units |
Aloe arborescens |
? |
- |
- |
2.3.1.B25 | more |
the plant type III polyketide synthase, oktaketide synthase (OKS) forms a non-reduced linear octaketide |
Aloe arborescens |
? |
- |
- |
2.3.1.B25 | more |
enzyme DynE8 makes 2, which is proposed to form the dynemicin enediyne and anthraquinone in the presence of accessory enzymes, and heptaene 1 in the presence of its native TE, DynE7. The end product is enediyne 3, synthesis pathway, overview |
Micromonospora chersina NRRL B-24756 |
? |
- |
- |