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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Show all pathways known for 2.3.1.239Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.239(3R,4R,5E,8R,10S,11S,12R)-3-hydroxy-4,8,10,12-tetramethyl-11-[[(2-nitrophenyl)methoxy]methoxy]-13-(phenylsulfanyl)tridec-5-en-7-one + methylmalonyl N-acetylcysteamine - Streptomyces venezuelae ? - ?
Show all pathways known for 2.3.1.239Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.239(3R,4R,5E,8R,10S,11S,12R)-3-hydroxy-4,8,10,12-tetramethyl-11-[[(2-nitrophenyl)methoxy]methoxy]-13-(phenylsulfanyl)tridec-5-en-7-one + methylmalonyl N-acetylcysteamine - Streptomyces venezuelae ATCC 15439 ? - ?
Show all pathways known for 2.3.1.239Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.239(E)-(2S,4R,8R,9R)-S-2-acetamidoethyl 9-hydroxy-2,4,8-trimethyl-5-oxoundec-6-enethioate + (2S)-methylmalonyl-CoA + NADPH + H+ pikromycin modules PikAIII and PikAIV generate the 12-membered ring macrocycle most efficiently when engaged in their native protein-protein interaction. PikAIV adopts an alternative conformation that enables the terminal thioesterase domain to directly off-load the PikAIII-bound hexaketide intermediate for macrocyclization Streptomyces venezuelae 10-deoxymethynolide + ? - ?
Show all pathways known for 2.3.1.239Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.239(E)-(2S,4R,8R,9R)-S-2-acetamidoethyl 9-hydroxy-2,4,8-trimethyl-5-oxoundec-6-enethioate + (2S)-methylmalonyl-CoA + NADPH + H+ the engineered polyketide synthase PikAIII-TE(thioesterase domain) fusion protein accepts and processes the pentaketide to produce 10-deoxymethynolide as the sole product. The polyketide synthase PikAIII/polyketide synthase PikAIV complex processes the pentaketide to produce 10-deoxymethynolide and narbonolide. After incubation of the hexaketide with polyketide synthase PikAIII-TE(thioesterase domain) fusion protein in both the presence and absence of NADPH, no product formation is observed Streptomyces venezuelae 10-deoxymethynolide + ? - ?
Show all pathways known for 2.3.1.239Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.239(E)-(2S,4R,8R,9R)-S-2-acetamidoethyl 9-hydroxy-2,4,8-trimethyl-5-oxoundec-6-enethioate + (2S)-methylmalonyl-CoA + NADPH + H+ the engineered polyketide synthase PikAIII-TE(thioesterase domain) fusion protein accepts and processes the pentaketide to produce 10-deoxymethynolide as the sole product. The polyketide synthase PikAIII/polyketide synthase PikAIV complex processes the pentaketide to produce 10-deoxymethynolide and narbonolide. After incubation of the hexaketide with polyketide synthase PikAIII-TE(thioesterase domain) fusion protein in both the presence and absence of NADPH, no product formation is observed Streptomyces venezuelae ATCC 15439 10-deoxymethynolide + ? - ?
Show all pathways known for 2.3.1.239Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.239malonyl-CoA + 5 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+ the product 10-deoxymethynolide is an intermediate in the biosynthesis of methymycin Streptomyces venezuelae 10-deoxymethynolide + 6 CoA + 6 CO2 + 5 NADP+ + 2 H2O - ?
Show all pathways known for 2.3.1.239Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.239malonyl-CoA + 5 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+ the enzyme also produces narbonolide (see EC 2.3.1.240, narbonolide synthase). The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain. Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP). Not all active sites are used in the biosynthesis Streptomyces venezuelae 10-deoxymethynolide + 6 CoA + 6 CO2 + 5 NADP+ + 2 H2O - ?
Show all pathways known for 2.3.1.239Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.239methylmalonyl-N-acetylcysteamine + S-phenyl (2S,4R,6E,8R,9R)-9-hydroxy-2,4,8-trimethyl-5-oxoundec-6-enethioate - Streptomyces venezuelae 3-dehydro-10-deoxymethynolide + 10-deoxymethynolide + CoA + CO2 + NADP+ + H2O products formed by chimeric polyketide synthase construcuts ?
Show all pathways known for 2.3.1.239Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.239methylmalonyl-N-acetylcysteamine + S-phenyl (2S,4R,6E,8R,9R)-9-hydroxy-2,4,8-trimethyl-5-oxoundec-6-enethioate - Streptomyces venezuelae ATCC 15439 3-dehydro-10-deoxymethynolide + 10-deoxymethynolide + CoA + CO2 + NADP+ + H2O products formed by chimeric polyketide synthase construcuts ?
Show all pathways known for 2.3.1.239Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.239more despite clear similarities in biochemistry and underlying module organization the picromycin synthase modules 5+TE(thioesterase) and 6+TE(thioesterase) show clear differences in substrate specificity and tolerance Streptomyces venezuelae ? - ?
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