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Results 1 - 4 of 4
EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the reaction diagram Show all sequences 2.3.1.236acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H+ - Streptomyces sahachiroi 5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+ - ?
Display the reaction diagram Show all sequences 2.3.1.236acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H+ - Streptomyces sahachiroi 5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+ incubation of substrates with isoform AziB alone leads to a truncated single-ring product, 2-methylbenzoic acid. Presence of thioesterase AziG acting as a chain elongation and cyclization domain is required for additional two rounds of chain extension to form the expected product, 5-methyl-1-naphthoate. None of the other thioesterase domains (AziA6, AziA7, AziA8) are capable of catalyzing the reaction ?
Display the reaction diagram Show all sequences 2.3.1.236acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H+ the multi-domain polyketide synthase involved in the synthesis of azinomycin B Streptomyces sahachiroi 5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+ - ?
Display the reaction diagram Show all sequences 2.3.1.236acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H+ - Streptomyces sahachiroi NRRL 2485 5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+ incubation of substrates with isoform AziB alone leads to a truncated single-ring product, 2-methylbenzoic acid. Presence of thioesterase AziG acting as a chain elongation and cyclization domain is required for additional two rounds of chain extension to form the expected product, 5-methyl-1-naphthoate. None of the other thioesterase domains (AziA6, AziA7, AziA8) are capable of catalyzing the reaction ?
Results 1 - 4 of 4