2.3.1.235 | 10 malonyl-CoA |
the multi-domain polyketide synthase involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN). A malonyl-CoA molecule is initially bound to the acyl carrier protein and decarboxylated to form an acetyl starter unit. Additional two-carbon units are added from nine more malonyl-CoA molecules |
Streptomyces glaucescens |
tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O |
tetracenomycin F2 i.e. 4-(3-acetyl-4,5,7,10-tetrahydroxyanthracen-2-yl)-3-oxobutanoic acid |
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