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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Show all pathways known for 2.3.1.226Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.226ethylmalonyl-CoA + (2S,5S)-carboxymethylproline + CO2 the substrate is an equilibrium mixture of L-glutamate semialdehyde, 5-hydroxy-L-proline and L-pyrroline-5-carboxylate. Some of the CarB variants catalyse the production of the two C6 epimers of (2S,5S)-6-ethyl-5-carboxymethylproline Pectobacterium carotovorum CoA + (2S,5S,6R)-6-ethyl-5-carboxymethylproline wild-type enzyme produces a 65:35 mixture of (6R)- and (6S)-epimer ?
Show all pathways known for 2.3.1.226Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.226ethylmalonyl-CoA + (2S,5S)-carboxymethylproline + CO2 the substrate is an equilibrium mixture of L-glutamate semialdehyde, 5-hydroxy-L-proline and L-pyrroline-5-carboxylate. Some of the CarB variants catalyse the production of the two C6 epimers of (2S,5S)-6-ethyl-5-carboxymethylproline Pectobacterium carotovorum CoA + (2S,5S,6S)-6-ethyl-5-carboxymethylproline wild-type enzyme produces a 65:35 mixture of (6R)- and (6S)-epimer ?
Show all pathways known for 2.3.1.226Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.226ethylmalonyl-CoA + L-2-aminoadipate semialdehyde activity with mutant enzymes W79F, W79F/M108A and W79F/M108V. mutant W79A: epimeric ethylmalonyl–CoA produces solely (2S,6S,7S)-(2S,6S)-carboxymethylpipecolic acid via reaction of (2R)-ethylmalonyl-CoA, whereas incubation of (2S)-ethylmalonyl–CoA and L-2-aminoadipate semialdehyde results in no detectable production of 7-ethyl-(2S,6S)-carboxymethylpipecolic acid Pectobacterium carotovorum CoA + (2S,6S,7R)-7-ethyl-carboxymethylpipecolic acid - ?
Show all pathways known for 2.3.1.226Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.226ethylmalonyl-CoA + L-2-aminoadipate semialdehyde activity with mutant enzymes W79F, W79F/M108A and W79F/M108V. mutant W79A: epimeric ethylmalonyl–CoA produces solely (2S,6S,7S)-(2S,6S)-carboxymethylpipecolic acid via reaction of (2R)-ethylmalonyl-CoA, whereas incubation of (2S)-ethylmalonyl–CoA and L-2-aminoadipate semialdehyde results in no detectable production of 7-ethyl-(2S,6S)-carboxymethylpipecolic acid Pectobacterium carotovorum CoA + (2S,6S,7S)-7-ethyl-carboxymethylpipecolic acid - ?
Show all pathways known for 2.3.1.226Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.226malonyl-CoA + (S)-1-pyrroline-5-carboxylate + H2O - Pectobacterium carotovorum CoA + (2S,5S)-5-carboxymethylproline + CO2 - ?
Show all pathways known for 2.3.1.226Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.226malonyl-CoA + (S)-1-pyrroline-5-carboxylate + H2O the enzyme catalyzes committed step in the biosynthesis of (5R)-carbapenem-3-carboxylic acid, the simplest of the medicinally important carbapenem antibiotics Pectobacterium carotovorum CoA + (2S,5S)-5-carboxymethylproline + CO2 - ?
Show all pathways known for 2.3.1.226Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.226malonyl-CoA + (S)-1-pyrroline-5-carboxylate + H2O acetyl-CoA is not a substrate Pectobacterium carotovorum CoA + (2S,5S)-5-carboxymethylproline + CO2 - ?
Show all pathways known for 2.3.1.226Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.226malonyl-CoA + (S)-1-pyrroline-5-carboxylate + H2O CarB is a member of the crotonase superfamily of enzymes. In addition to decarboxylation and thioester hydrolysis steps, it catalyzes C-C bond formation leading to a substituted heterocycle. Mechanistic studies show that C-C bond formation by CarB most probably occurs by reaction of P5C with an oxy-anion stabilized enolate, and thioester hydrolysis most probably proceeds by direct attack of an activated water molecule Pectobacterium carotovorum CoA + (2S,5S)-5-carboxymethylproline + CO2 - ?
Show all pathways known for 2.3.1.226Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.226malonyl-CoA + (S)-1-pyrroline-5-carboxylate + H2O the substrate is an equilibrium mixture of L-glutamate semialdehyde, 5-hydroxy-L-proline and L-pyrroline-5-carboxylate Pectobacterium carotovorum CoA + (2S,5S)-5-carboxymethylproline + CO2 - ?
Show all pathways known for 2.3.1.226Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.226malonyl-CoA + (S)-1-pyrroline-5-carboxylate + H2O - Pectobacterium carotovorum GS101 CoA + (2S,5S)-5-carboxymethylproline + CO2 - ?
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