EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.3.1.212 | 3 (2RS)-methylmalonyl-CoA + H2O |
- |
Rheum palmatum |
6-ethyl-4-hydroxy-3,5-dimethyl-2-pyrone + ? |
a methylated C9 triketide |
? |
2.3.1.212 | 4-coumaroyl-CoA + (2RS)-methylmalonyl-CoA + H2O |
- |
Rheum palmatum |
2 CoA + 1-(4-hydroxyphenyl)pent-1-en-3-one + 2 CO2 |
an unnatural novel diketide |
? |
2.3.1.212 | 4-coumaroyl-CoA + malonyl-CoA + H2O |
- |
Rubus idaeus |
2 CoA + 4-hydroxybenzalacetone + 2 CO2 |
- |
? |
2.3.1.212 | 4-coumaroyl-CoA + malonyl-CoA + H2O |
- |
Rheum palmatum |
2 CoA + 4-hydroxybenzalacetone + 2 CO2 |
- |
? |
2.3.1.212 | 4-coumaroyl-CoA + malonyl-CoA + H2O |
a one-step decarboxylative condensation at pH 8.0 |
Rheum palmatum |
2 CoA + 4-hydroxybenzalacetone + 2 CO2 |
i.e. 4-(4-hydroxyphenyl)but-3-en-2-one |
? |
2.3.1.212 | 4-coumaroyl-CoA + malonyl-CoA + H2O |
BAS catalyzes the decarboxylative coupling of 4-coumaroyl-CoA with malonyl-CoA to produce the diketide benzalacetone |
Rheum palmatum |
2 CoA + 4-hydroxybenzalacetone + 2 CO2 |
- |
? |
2.3.1.212 | 4-coumaroyl-CoA + malonyl-CoA + H2O |
high activity with 4-coumaroyl-CoA |
Rubus idaeus |
2 CoA + 4-hydroxybenzalacetone + 2 CO2 |
- |
? |
2.3.1.212 | 4-coumaroyl-CoA + malonyl-CoA + H2O |
one-step condensation |
Rheum palmatum |
2 CoA + 4-hydroxybenzalacetone + 2 CO2 |
- |
? |
2.3.1.212 | 4-coumaroyl-CoA + malonyl-CoA + H2O |
one-step decarboxylative condensation of 4-coumaroyl-CoA with malonyl-CoA to produce the diketide 4-(4-hydroxyphenyl)-but-3-en-2-one |
Rheum palmatum |
2 CoA + 4-hydroxybenzalacetone + 2 CO2 |
- |
? |
2.3.1.212 | 4-coumaroyl-CoA + malonyl-CoA + H2O |
the enzyme catalyzes the formation of unnatural 2-substituted quinolones and 1,3-diketones via head-to-head condensation of two completely different substrates. The broad range of substrate tolerance of HsPKS3 facilitates accessing structurally diverse 2-substituted quinolones and 1,3-diketones |
Huperzia serrata |
2 CoA + 4-hydroxybenzalacetone + 2 CO2 |
- |
? |