EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.3.1.161 | (4E,6E)-2-methyl-3-oxoocta-4,6-dienoyl-S-ACP + NADPH + H+ |
reaction of ketoreductase subunit, natural substrate. ACP = acyl-carrier protein |
Aspergillus terreus |
(4E,6E)-2-methyl-3-hydroxyocta-4,6-dienoyl-S-ACP + NADP+ |
- |
? |
2.3.1.161 | (4E,6E)-3-oxoocta-4,6-dienoyl-N-acetylcysteamine + S-adenosyl-L-methionine |
reaction of methyltransferase subunit, natural substrate analogue. ACP = acyl-carrier protein |
Aspergillus terreus |
(4E,6E)-2-methyl-3-oxoocta-4,6-dienoyl-N-acetylcysteamine + S-adenosyl-L-homocysteine |
- |
? |
2.3.1.161 | (4E,6E)-3-oxoocta-4,6-dienoyl-S-ACP + S-adenosyl-L-methionine |
reaction of methyltransferase subunit, natural substrate. ACP = acyl-carrier protein |
Aspergillus terreus |
(4E,6E)-2-methyl-3-oxoocta-4,6-dienoyl-S-ACP + S-adenosyl-L-homocysteine |
- |
? |
2.3.1.161 | 2-methyl-3-oxohexanoyl-N-acetylcysteamine + NADPH + H+ |
reaction of ketoreductase subunit, natural substrate |
Aspergillus terreus |
3-hydroxy-2-methylhexanoyl-N-acetylcysteamine + NADP+ |
- |
? |
2.3.1.161 | 3-oxohexanoyl-N-acetylcysteamine + NADPH + H+ |
reaction of ketoreductase subunit, natural substrate |
Aspergillus terreus |
3-hydroxyhexanoyl-N-acetylcysteamine + NADP+ |
- |
? |
2.3.1.161 | 3-oxooctanoyl-N-acetylcysteamine + S-adenosyl-L-methionine |
reaction of methyltransferase subunit, artificial substrate. 0.3% of the activity with (4E,6E)-3-oxoocta-4,6-dienoyl-N-acetylcysteamine |
Aspergillus terreus |
2-methyl-3-oxooctanoyl-N-acetylcysteamine + S-adenosyl-L-homocysteine |
- |
? |
2.3.1.161 | acetyl-CoA + 8 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + 11 H+ |
reaction mechanism |
Aspergillus terreus |
dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O |
- |
? |
2.3.1.161 | acetyl-CoA + 8 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + 11 H+ |
enzyme contains six active sites: ketosynthase, acyltransferase, dehydratase, enoyl reductase, ketoreductase and acyl carrier protein |
Aspergillus terreus |
dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O |
- |
? |
2.3.1.161 | acetyl-CoA + 8 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + 11 H+ |
enzyme also displays Diels-Alderase activity in vitro |
Aspergillus terreus |
dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O |
- |
? |
2.3.1.161 | acetyl-CoA + 8 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + 11 H+ |
reaction mechanism, interaction with LovC |
Aspergillus terreus |
dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O |
- |
? |