EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
  2.1.1.85 | more |
no activity with histone H3 L-lysine4 (1-23), histone H3 L-lysine36 (25-47), and beta-actin (66-88) H73A mutant |
Homo sapiens |
? |
- |
- |
| 2.1.1.85 | more |
no activity with human beta-actin mutant H73A, ATP-bound actin or ADP-bound actin |
Rattus norvegicus |
? |
- |
- |
| 2.1.1.85 | more |
the enzyme does not methylate histones and shows no activity on actin I71A/W79E double mutations |
Homo sapiens |
? |
- |
- |
| 2.1.1.85 | more |
the enzyme has weak lysine methylation activity on an actin peptide in which the target His73 is substituted by a L-lysine |
Homo sapiens |
? |
- |
- |
| 2.1.1.85 | S-adenosyl-L-methionine + actin L-histidine73 |
- |
Mus musculus |
S-adenosyl-L-homocysteine + actin Ntau-methyl-L-histidine73 |
- |
? |
| 2.1.1.85 | S-adenosyl-L-methionine + actin L-histidine73 |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + actin Ntau-methyl-L-histidine73 |
- |
? |
| 2.1.1.85 | S-adenosyl-L-methionine + actin L-histidine73 |
in a pre-reactive complex the enzyme binds the N3-protonated form of actin His73, and in a post-reactive product complex, the enzyme generates the methylated histidine in an N1-protonated and N3-methylated form |
Homo sapiens |
S-adenosyl-L-homocysteine + actin Ntau-methyl-L-histidine73 |
- |
? |
| 2.1.1.85 | S-adenosyl-L-methionine + beta-actin L-histidine73 |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + beta-actin Ntau-methyl-L-histidine73 |
- |
? |
| 2.1.1.85 | S-adenosyl-L-methionine + human beta-actin (residues 66-80) |
sequence TLKYPIEHGIVTNWD |
Homo sapiens |
S-adenosyl-L-homocysteine + human beta-actin (residues 66-80) Ntau-methyl-L-histidine |
- |
? |
| 2.1.1.85 | S-adenosyl-L-methionine + human beta-actin L-histidine73 |
- |
Rattus norvegicus |
S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine73 |
- |
? |
