EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.1.1.364 | ARTKQTARKSTGGKAPRK(biot)G + S-adenosyl-L-methionine |
- |
Homo sapiens |
ART-methyl-KQTARKSTGGKAPRK(biot)G + S-adenosyl-L-homocysteine |
- |
? |
| 2.1.1.364 | more |
methyl-transfer reaction catalyzed by SET7/9 is a typical in-line SN2 nucleophilic substitution reaction with a transition state of 70% dissociative character, transfers only one methyl group to the unmodified histone-lysine residue H3-K4 |
Homo sapiens |
? |
- |
? |
| 2.1.1.364 | more |
SET7/9 plays an essential catalytic role in significantly lowering the barrier for the methyl-transfer reaction step |
Homo sapiens |
? |
- |
? |
| 2.1.1.364 | more |
modification of histone tails |
Homo sapiens |
? |
- |
? |
| 2.1.1.364 | S-adenosyl-L-methionine + histone (K4) |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + methylated histone (K4) |
- |
? |
| 2.1.1.364 | S-adenosyl-L-methionine + histone H3 |
- |
Homo sapiens |
? |
- |
? |
| 2.1.1.364 | S-adenosyl-L-methionine + histone H3(K4) |
- |
Homo sapiens |
? |
- |
? |
| 2.1.1.364 | S-adenosyl-L-methionine + histone H3(K4) |
SET7/9 only catalyzes the transfer of one methyl group to the target lysine |
Homo sapiens |
? |
- |
? |
| 2.1.1.364 | S-adenosyl-L-methionine + histone L-lysine |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine |
- |
? |
| 2.1.1.364 | S-adenosyl-L-methionine + histone L-lysine |
the wild-type SET7/9 is a monomethylase |
Homo sapiens |
S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine |
- |
? |
