Any feedback?
Please rate this page
(search_result.php)
(0/150)

BRENDA support

Refine search

Search Substrates and Products (Substrate)

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search

Search term:

Results 1 - 10 of 17 > >>
download as CSV
download all results as CSV
EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.3572 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction Homo sapiens 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36 - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.3572 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction Mus musculus 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36 - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.3572 S-adenosyl-L-methionine + [histone H3]-L-lysine36 - Homo sapiens 2 S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine36 - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.357more enzyme mono- and dimethylates H3K36 and is inactive with H3K4 as substrate. Nucleosome containing histone H3 mutant K36A or histone H3 peptide 18-44 are not substrates. Isoform SETD2 is able to trimethylate H3K36 in vitro Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.357more the enzyme does not methylate free histone octamers or (H3-H4)2 tetramers bound to DNA Mus musculus ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.357more the catalytic domain does not methylate recombinant nucleosomes containing histone H3 K36A mutants Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.357more enzyme shows versatilitiy in substrate recognition. In a pan-methylation assay of histone H3, H3K4me3 and H3K27me3 species are preferably detected rather than me1 and me2 species, while H3K9-me1 and -me2 and H3K79-me1 and -me2 species are favored against me3 species. H3K36 appears to be the preferable in vitro substrate for NSD1-C-terminal domain. NSD1 shows mono-/tri-methylation of histone H4K20 Homo sapiens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.357S-adenosyl-L-homocysteine + nuclear factor-kappaB NSD1 also methylates nonhistone proteins, including the p65 subunit of nuclear factor-kappaB at Lys218 and Lys221 Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.357S-adenosyl-L-homocysteine + p65 subunit of nuclear factor-kappaB - Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.357S-adenosyl-L-methionine + a [histone H3]-L-lysine36 - Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36 - ?
Results 1 - 10 of 17 > >>
download as CSV
download all results as CSV