  2.1.1.351 | S-adenosyl-L-methionine + nocamycin E |
the enzyme is involved in the biosynthesis of nocamycin I and nocamycin II, which both show antimicrobial activity. Compared to nocamycin I, nocamycin E shows inferior antibacterial activity, indicating the methyl group is essential to antibacterial activity |
Saccharothrix syringae |
S-adenosyl-L-homocysteine + nocamycin I |
- |
? |
| 2.1.1.351 | S-adenosyl-L-methionine + nocamycin E |
nocamycin E i.e. (2R,3S,3aS,5R,6R,7S,9aS)-5-[(2R,3E,5E)-7-hydroxy-4-methyl-7-(2,4-dioxopyrroliden-3-ylidene)hepta-3,5-dien-2-yl]-2,6,9a-trimethyl-8-oxooctahydro-3a,7-epoxyfuro[3,2-b]oxocine-3-carboxylate. Nocamycin I i.e. methyl (2R,3S,3aS,5R,6R,7S,9aS)-5-[(2R,3E,5E)-7-hydroxy-4-methyl-7-(2,4-dioxopyrroliden-3-ylidene)hepta-3,5-dien-2-yl]-2,6,9a-trimethyl-8-oxooctahydro-3a,7-epoxyfuro[3,2-b]oxocine-3-carboxylate |
Saccharothrix syringae |
S-adenosyl-L-homocysteine + nocamycin I |
- |
? |
