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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.348more both METTL3 and METTL14 preferentially methylate RNA substrates containing the consensus sequence GGACU. RNA probes containing consensus sequence GGAUU show a 10- to 60fold decrease in methylation. The combination of METTL3/METTL14 exhibits slightly higher activity towards probe with sequence GGACU in the stem than probe with sequence GGACU in the loop Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.348more consensus sequence for methylation of RNA is GGACU. The single transition mutation, GGACU to GGAUU, is sufficient to significantly reduce methylation levels Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.348more in WTAP- and METTL3 intronic binding clusters, the RNA motifs AGGACU and UGUGGACU are enriched. The highest scoring motif found in both WTAP- and METTL3-binding clusters is UUAGGACU. In addition, AGGAC, UGGAC, and AGACUAA are also highly enriched in WTAP, METTL3 and WTAP/METTL3 overlay clusters, respectively Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.348more in the enzyme complex, METTL3 primarily functions as the catalytic core, while METTL14 serves as an RNA-binding platform Homo sapiens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.348more no activity with RNA probe 5-GGGCUGGGCUGGGCUGGGCU-3 Homo sapiens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.348more the enzyme preferentially methylates substrates containing the consensus sequence Pu[G>A]m6AC[U>A>C], but exhibit no obvious preference to the stem-loop structure for N6-methyladenine deposition Homo sapiens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.348S-adenosyl-L-methionine + 5-GGACUGGACUGGACUGGACU-3 - Homo sapiens S-adenosyl-L-homocysteine + 5-GGm6ACUGGm6ACUGGm6ACUGGm6ACU-3 - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.348S-adenosyl-L-methionine + adenine in 5'-UACACUCGAUCU-GGACU-AAAGCUGCUC - Homo sapiens homocysteine + 5'-UACACUCGAUCU-GG-(N6-methyl)ACU-AAAGCUGCUC - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.348S-adenosyl-L-methionine + adenine in mRNA - Homo sapiens S-adenosyl-L-homocysteine + N6-methyladenine in mRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.348S-adenosyl-L-methionine + adenine in mRNA - Oryza sativa S-adenosyl-L-homocysteine + N6-methyladenine in mRNA - ?
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