EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.346 | more |
U6 snRNA lacking the stem-loop near the 5' end is as efficient a substrate as the full-length U6 snRNA. U6 snRNA(41-106) is not methylated efficiently. Deletion of 19 nucleotides of the 3' end stem-loop structure (U6 snRNA(1-88)) reduces the efficiency to 20-45% of the wild-type, and U6 snRNA(1-67) does not serves as substrate at all |
Homo sapiens |
? |
- |
? |
2.1.1.346 | S-adenosyl-L-methionine + adenine in MAT2A hairpin 1 |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + N6-methyladenine in MAT2A hairpin 1 |
- |
? |
2.1.1.346 | S-adenosyl-L-methionine + adenine in U6 lncRNA |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + N6-methyladenine in U6 lncRNA |
- |
? |
2.1.1.346 | S-adenosyl-L-methionine + adenine in U6 ncRNA |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + N6-methyladenine in U6 ncRNA |
- |
? |
2.1.1.346 | S-adenosyl-L-methionine + adenine in U6 pre-mRNA |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + N6-methyladenine in U6 pre-mRNA |
- |
? |
2.1.1.346 | S-adenosyl-L-methionine + adenine in U6 snRNA |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA |
- |
? |
2.1.1.346 | S-adenosyl-L-methionine + adenine in U6 snRNA |
the enzyme is responsible for N6-methylation of A43 of the U6 snRNA |
Homo sapiens |
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA |
- |
? |
2.1.1.346 | S-adenosyl-L-methionine + adenine in U6 snRNA |
regulation of Mat2a mRNA by Mettl16 is essential for mouse embryonic development |
Homo sapiens |
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA |
- |
? |
2.1.1.346 | S-adenosyl-L-methionine + adenine in U6 snRNA |
regulation of Mat2a mRNA by Mettl16 is essential for mouse embryonic development |
Mus musculus |
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA |
- |
? |
2.1.1.346 | S-adenosyl-L-methionine + adenine in U6 snRNA |
the enzyme methylates U6 spliceosomal RNA and interacts with the 3'-terminal RNA triple helix of MALAT1 (metastasis-associated lung adenocarcinoma transcript 1). Full-length METTL16 binds to the MALAT1 RNA triple helix, but monomeric METTL16_291 does not |
Homo sapiens |
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA |
- |
? |