EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.337 | 2 S-adenosyl-L-methionine + (S)-coclaurine |
the mutant enzyme G204E produces (S)-N-methylcoclaurine and (S)-N,N-dimethylcoclaurine in a roughly 2:1 ratio |
Papaver somniferum |
2 S-adenosyl-L-homocysteine + (S)-N,N-dimethylcoclaurine |
- |
? |
2.1.1.337 | more |
RNMT shows a strong preference for substrates with a tertiary amine, although alkaloids containing a secondary amine (e.g. (R,S)-tetrahydropapaverine, (S)-coclaurine) are also accepted as substrates. In the case of substrates with secondary amines, RNMT catalyzes two sequential N-methylations |
Papaver somniferum |
? |
- |
? |
2.1.1.337 | more |
RNMT shows a strong preference for substrates with a tertiary amine, although alkaloids containing a secondary amine (e.g. (R,S)-tetrahydropapaverine) are also accepted as substrates. In the case of substrates with secondary amines, RNMT catalyzes two sequential N-methylations |
Papaver somniferum |
? |
- |
? |
2.1.1.337 | S-adenosyl-L-methionine + (+)-bulbocapnine |
75% substrate conversion |
Papaver somniferum |
S-adenosyl-L-homocysteine + ? |
- |
? |
2.1.1.337 | S-adenosyl-L-methionine + (+)-glaucine |
47% substrate conversion |
Papaver somniferum |
S-adenosyl-L-homocysteine + ? |
- |
? |
2.1.1.337 | S-adenosyl-L-methionine + (R)-reticuline |
98% substrate conversion |
Papaver somniferum |
S-adenosyl-L-homocysteine + (S)-tembetarine |
- |
? |
2.1.1.337 | S-adenosyl-L-methionine + (R,S)-tetrahydropapaverine |
24% substrate conversion |
Papaver somniferum |
S-adenosyl-L-homocysteine + ? |
- |
? |
2.1.1.337 | S-adenosyl-L-methionine + (S)-coclaurine |
reaction of EC 2.1.1.140 |
Papaver somniferum |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine |
- |
? |
2.1.1.337 | S-adenosyl-L-methionine + (S)-coclaurine |
the mutant enzyme G204E produces (S)-N-methylcoclaurine and (S)-N,N-dimethylcoclaurine in a roughly 2:1 ratio |
Papaver somniferum |
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine |
- |
? |
2.1.1.337 | S-adenosyl-L-methionine + (S)-corytuberine |
82% substrate conversion |
Papaver somniferum |
S-adenosyl-L-homocysteine + magnoflorine |
- |
? |